The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis
| Autor: | Silvan Vesenbeckh, Sonja Dr. Dipl.-Biochem. Wagner, Harald Mauch, Thorsten Bergmann, Torsten T. Bauer, Holger Rüssmann, Nicolas Schönfeld |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Tuberculosis
biology Latent tuberculosis Article Subject business.industry lcsh:R lcsh:Medicine Consecutive case series biology.organism_classification medicine.disease Active tuberculosis Mycobacterium tuberculosis Immunology Clinical Study Medicine Interferon gamma Differential diagnosis Mycobacterium tuberculosis culture business medicine.drug |
| Zdroj: | Tuberculosis Research and Treatment Tuberculosis Research and Treatment, Vol 2012 (2012) |
| ISSN: | 2090-1518 2090-150X |
| Popis: | Interferon gamma release assays (IGRAs) arein vitroimmunologic diagnostic tests used to identifyMycobacterium tuberculosisinfection. They cannot differentiate between latent and active infections. The cutoff suggested by the manufacturer is 0.35 IU/mL for latent tuberculosis. As IGRA tests were recently approved for the differential diagnosis of active tuberculosis, we assessed the diagnostic accuracy of the latest generation IGRA for detection of active tuberculosis in a low-incidence area in Germany. Our consecutive case series includes 61 HIV negative,Mycobacterium tuberculosisculture positive patients, as well as 234 control patients. The retrospective analysis was performed over a period of two years. In 11/61 patients with active tuberculosis (18.0%) the test result was |
| Databáze: | OpenAIRE |
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