Pleiotropic effects of polyphenols on glucose and lipid metabolism: Focus on clinical trials
| Autor: | Francesco Amenta, E. Espinosa, Felicia Gurău, Francesco Prattichizzo, Angelica Giuliani, Armanda Pugnaloni, Simone Baldoni, Jacopo Sabbatinelli, Maria Rita Rippo, Massimiliano Bonafè, Giulia Matacchione, Andrea Silvestrini, Antonio Domenico Procopio, Fabiola Olivieri |
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| Přispěvatelé: | Matacchione G., Gurau F., Baldoni S., Prattichizzo F., Silvestrini A., Giuliani A., Pugnaloni A., Espinosa E., Amenta F., Bonafe' M., Procopio A.D., Rippo M.R., Olivieri F., Sabbatinelli J. |
| Rok vydání: | 2020 |
| Předmět: |
Polyphenol
0301 basic medicine Aging medicine.medical_specialty endocrine system diseases Type 2 diabetes Disease Biochemistry Type 2 diabete 03 medical and health sciences 0302 clinical medicine Nutraceutical medicine Humans Intensive care medicine Molecular Biology business.industry Polyphenols nutritional and metabolic diseases Type 2 Diabetes Mellitus Lipid Metabolism medicine.disease Metabolic syndrome Diet Clinical trial Glucose 030104 developmental biology Dyslipidemia Diabetes Mellitus Type 2 Neurology Observational study Energy Metabolism business 030217 neurology & neurosurgery Human Biotechnology |
| Zdroj: | Ageing Research Reviews. 61:101074 |
| ISSN: | 1568-1637 |
| Popis: | Epidemiological evidence from observational studies suggests that dietary polyphenols (PPs) – phytochemicals found in a variety of plant-based foods – can reduce the risk of developing type 2 diabetes mellitus (T2DM). Clinical trials have also indicated that PPs may help manage the two key features of T2DM, hyperglycemia and dyslipidemia. Since the incidence of T2DM is dramatically increasing worldwide, identifying food-based approaches that can reduce the risk of developing it and help manage its main risk factors in early-stage disease has clinical and socioeconomic relevance. After a brief overview of current epidemiological data on the incidence of T2DM in individuals consuming PP-rich diets, we review the evidence from clinical trials investigating PP-enriched foods and/or PP-based nutraceutical compounds, report their main results, and highlight the knowledge gaps that should be bridged to enhance our understanding of the role of PPs in T2DM development and management. |
| Databáze: | OpenAIRE |
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