Sublingual Immunotherapy in the Treatment of Atopic Dermatitis: a Systematic Review Using the GRADE System
| Autor: | David M. Lang, Samantha R. Gendelman |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pulmonary and Respiratory Medicine
Sublingual Immunotherapy Allergen immunotherapy Allergy medicine.medical_specialty Randomization Intention-to-treat analysis business.industry Immunology Administration Sublingual MEDLINE Immunoglobulins Aeroallergen Atopic dermatitis Allergens medicine.disease_cause medicine.disease Dermatology Dermatitis Atopic body regions medicine Humans Immunology and Allergy Sublingual immunotherapy business |
| Zdroj: | Current Allergy and Asthma Reports. 15 |
| ISSN: | 1534-6315 1529-7322 |
| DOI: | 10.1007/s11882-014-0498-5 |
| Popis: | Controversy exists regarding the role of allergen immunotherapy as a therapeutic intervention for patients with atopic dermatitis and aeroallergen sensitivity. Our aim was to critically appraise the evidence supporting the use of sublingual immunotherapy for patients with atopic dermatitis and aeroallergen sensitivity. We performed a literature search using the terms "sublingual immunotherapy" and "atopic dermatitis" and "sublingual immunotherapy" and "eczema." We used the same terms to search PubMed, Ovid, and Scopus. Our limits were "Humans" and "English." We excluded articles that were not in English. These articles were analyzed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Many studies reported improvement in clinical symptoms of atopic dermatitis. Serious methodological shortcomings were noted including but not limited to lack of control group, lack of randomization, incomplete descriptions of randomization and/or allocation concealment, many enrolled subjects not completing participation, and/or data analysis not by intention to treat. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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