Ischemic patterns assessed by positron emission tomography predict adverse outcome in patients with idiopathic dilated cardiomyopathy

Autor: René A. Tio, Riemer H. J. A. Slart, Richard M. de Jong, Paul Michel Koning, Clark J. Zeebregts, Adriaan A. Voors, Dirk J. van Veldhuisen, Pim van der Harst, Rudi Dierckx
Přispěvatelé: Man, Biomaterials and Microbes (MBM), Cardiovascular Centre (CVC), Vascular Ageing Programme (VAP), Translational Immunology Groningen (TRIGR)
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Male
DOWN-REGULATION
positron emission tomography
medicine.medical_treatment
Comorbidity
Coronary artery disease
Risk Factors
CARDIAC PET
Prevalence
Netherlands
CONGESTIVE CARDIOMYOPATHY
VENTRICULAR DYSFUNCTION
medicine.diagnostic_test
MYOCARDIAL BLOOD-FLOW
Dilated cardiomyopathy
Middle Aged
Survival Rate
myocardial ischemia
Positron emission tomography
Cardiac PET
Radiology Nuclear Medicine and imaging
Cardiology
CORONARY-ARTERY-DISEASE
HEART-FAILURE
Female
Original Article
REVASCULARIZATION
Cardiology and Cardiovascular Medicine
Perfusion
myocardial perfusion
Cardiomyopathy
Dilated
medicine.medical_specialty
Heart failure
IMPROVEMENT
Revascularization
Risk Assessment
Internal medicine
Idiopathic dilated cardiomyopathy
medicine
Humans
Radiology
Nuclear Medicine and imaging
cardiovascular diseases
business.industry
medicine.disease
Survival Analysis
VIABILITY
dilated cardiomyopathy
Positron-Emission Tomography
business
Zdroj: Journal of Nuclear Cardiology
Journal of Nuclear Cardiology, 16(5), 769-774. SPRINGER
ISSN: 1071-3581
Popis: Background Although patients with idiopathic dilated cardiomyopathy (DCM) have no coronary artery disease, regional impairment of myocardial perfusion combined with preserved metabolism has been found using positron emission tomography (PET). Our aim was to assess the prognostic relevance of PET-mismatch between stress myocardial perfusion and glucose uptake on clinical outcome in DCM. Methods In 24 patients with DCM who underwent both myocardial perfusion and metabolism PET scanning, “mismatch” was assessed and the association with clinical outcome (hospitalization, mortality, and heart transplantation) was investigated. Results Mismatch was found in 16 patients (66.7%). Univariate analysis showed that the presence of mismatch was associated with adverse outcome (P = 0.03). After adjustment for sex and age, the association remained significant with an adjusted relative risk of 10.4 (95% CI 1.1-103; P = 0.04) for death, heart transplant, or hospitalization. Univariate analysis also showed that a higher extent of mismatch was significantly associated with adverse outcome (P = 0.02). After adjusting for sex and age, the association remained significant with an adjusted relative risk of 6.5 [95% CI 1.2-36; P = 0.03] for death, heart transplantation, or hospitalization. Conclusion PET stress perfusion-metabolism mismatch, indicative for ischemia, is frequently found in DCM patients and related to a poorer outcome.
Databáze: OpenAIRE
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