Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru
| Autor: | Katty Borrini-Mayori, Dustin Brisson, Jenny Ancca-Juarez, Ricardo Castillo-Neyra, Claudia Chipana-Ramos, Melina Vargas-Maquera, Alexander S. F. Berry, Cesar Naquira-Velarde, Claudia Arevalo-Nieto, Michael J. Levy, Renzo Salazar-Sánchez |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Heredity RC955-962 Population structure Social Sciences Population genetics Disease Vectors Zoonotic disease Gene flow 0302 clinical medicine Arctic medicine. Tropical medicine Peru Medicine and Health Sciences Phylogeny Data Management Protozoans Mammals Molecular Epidemiology 0303 health sciences education.field_of_study Geography biology Ecology Eukaryota Phylogenetic Analysis Animal Models Phylogenetics Chagas Disease/epidemiology/parasitology/transmission Infectious Diseases Experimental Organism Systems Animals Domestic Vertebrates Genetic structure Public aspects of medicine RA1-1270 purl.org/pe-repo/ocde/ford#3.03.06 [https] Research Article Gene Flow Chagas disease Trypanosoma Computer and Information Sciences Genotype Animals Domestic/parasitology Trypanosoma cruzi Guinea Pigs 030231 tropical medicine Population Research and Analysis Methods Human Geography Rodents 03 medical and health sciences Urbanization parasitic diseases Genetics Parasitic Diseases Disease Transmission Infectious medicine Humans Animals Chagas Disease Evolutionary Systematics education Taxonomy 030304 developmental biology Evolutionary Biology Population Biology Molecular epidemiology Organisms Public Health Environmental and Occupational Health Biology and Life Sciences Trypanosoma cruzi/classification/genetics/isolation & purification biology.organism_classification medicine.disease Parasitic Protozoans Vector-Borne Diseases 030104 developmental biology Amniotes Animal Studies Earth Sciences Human Mobility Biological dispersal Peru/epidemiology Population Genetics |
| Zdroj: | PLoS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0007910 (2020) |
| Popis: | Anthropogenic environmental alterations such as urbanization can threaten native populations as well as create novel environments that allow human pests and pathogens to thrive. As the number and size of urban environments increase globally, it is more important than ever to understand the dispersal dynamics of hosts, vectors and pathogens of zoonotic disease systems. For example, a protozoan parasite and the causative agent of Chagas disease in humans, Trypanosoma cruzi, recently colonized and spread through the city of Arequipa, Peru. We used population genomic and phylogenomic tools to analyze whole genomes of 123 T. cruzi isolates derived from vectors and non-human mammals throughout Arequipa to determine patterns of T. cruzi dispersal. The data show significant population genetic structure within city blocks—parasites in the same block tend to be very closely related—but no population structure among blocks within districts—parasites in neighboring blocks are no more closely related to one another than to parasites in distant districts. These data suggest that T. cruzi dispersal within a block occurs regularly and that occasional long-range dispersal events allow the establishment of new T. cruzi populations in distant blocks. Movement of domestic animals may be the primary mechanism of inter-block and inter-district T. cruzi dispersal. Author summary Urbanization creates environments that are ideal for some human pests and pathogens. As the number and size of urban environments increases globally, it is becoming vital to understand how human disease-causing pathogens, their vectors, and their non-human hosts disperse through urban landscapes. Here we study a population of Trypanosoma cruzi–the protozoan parasite and causative agent of Chagas disease in humans–that recently colonized the city of Arequipa, Peru. We use population genomic and phylogenomic tools to understand how this parasite population dispersed through the city to achieve its current distribution and abundance. We show that T. cruzi collected from the same city block tend to be very closely related, while those from neighboring blocks are often as distantly related as those from blocks in distant districts. The data suggest that vectors facilitate frequent within-block dispersal of the parasite, while domestic animal movement may facilitate the relatively infrequent inter-block and inter-district dispersal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|