Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds
| Autor: | Gastón Repossi, Mirta A. Valentich, Julián C. Rivas-Gonzalo, M. Teresa Escribano-Bailón, Ignacio García-Estévez, Elio Andres Soria, María Cecilia Cittadini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Aspidosperma
0301 basic medicine Cancer Research Medicine (miscellaneous) Ciencias de la Salud Medicina Clínica chemistry.chemical_compound 0302 clinical medicine interleucina-6 chemistry.chemical_classification Nutrition and Dietetics Aspidosperma quebracho-blanco biology Chemistry Fatty Acids Lantana grisebachii Glioma Phenolic Compounds Medicina Básica Oncology Biochemistry 030220 oncology & carcinogenesis Medicina Critica y de Emergencia American Tea Extracts Polyunsaturated fatty acid CIENCIAS MÉDICAS Y DE LA SALUD Lantana Inmunología 03 medical and health sciences Phenols Ilex paraguariensis Cell Line Tumor medicine Animals Humans Interleukin 6 ácidos grasos Salud Ocupacional Plant Extracts Interleukin-6 Fatty acid Resazurin South America biology.organism_classification medicine.disease Glioma Cells Phenolic compounds Rats 030104 developmental biology Cell culture biology.protein Gas chromatography Teas Herbal |
| Zdroj: | GREDOS. Repositorio Institucional de la Universidad de Salamanca instname |
| DOI: | 10.1080/01635581.2018.1412484 |
| Popis: | Dietary phenolic compounds are plant metabolites with beneficial effects on the central nervous system. Thus, our aim was to identify anti-inflammatory compounds from South American plants on glia, which regulates neuro-immune response. The compounds were extracted from Lantana grisebachii (LG), Aspidosperma quebracho-blanco (AQB), and Ilex paraguariensis (IP) teas and identified by HPLC-DAD-MS. Extracts (0–200 µg/ml) were tested on human T98-G and rat C6 glioma lines. Cellular viability (by the resazurin assay), fatty acid profile (by gas chromatography) and pro-inflammatory interleukin-6 release (IL-6 by ELISA) were determined. Data were analyzed by partial least-square regression to discriminate bioactive compounds. Twenty-one compounds were determined in LG, mainly iridoids, which were linked to ω-3 and ω-6 polyunsaturated fatty acids, but not to IL-6 release. Thirty-one compounds were found in AQB, mostly hydroxybenzoic derivatives, which were positively related to IL-6 release. Twenty-three compounds were identified in IP, including caffeoylquinic derivatives and mainly chlorogenic acid. They increased the ω-7 palmitoleic fatty acid, which was related to IL-6 decrease. These results enhances phytochemical knowledge of widely available plants, and suggest the lipid-related anti-inflammatory activity of IP phenolic compounds, which give nutritional relevance to the tea. Fil: Cittadini, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Ministerio de Salud; Argentina Fil: García Estévez, Ignacio. Universidad de Salamanca; España Fil: Escribano Bailón, M. Teresa. Universidad de Salamanca; España Fil: Rivas Gonzalo, Julián C.. Universidad de Salamanca; España Fil: Valentich, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina Fil: Repossi Marquez, Pablo Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina Fil: Soria, Elio Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina |
| Databáze: | OpenAIRE |
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