Inflammatory central nervous system disease in lupus-prone MRL/lpr mice: comparative histologic and immunohistochemical findings
| Autor: | Joe Basler, Cynthia Besch-Williford, Gayle C. Johnson, Sara E. Walker, Catherine M. Vogelweid |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pathology
medicine.medical_specialty T cell Immunology Central nervous system Inflammation urologic and male genital diseases medicine.disease_cause Immunoglobulin G Autoimmunity Mice Neuritis immune system diseases medicine Immunology and Allergy Animals Lupus Erythematosus Systemic skin and connective tissue diseases Brain Diseases Lupus erythematosus Systemic lupus erythematosus biology business.industry Brain medicine.disease Immunohistochemistry Mice Mutant Strains medicine.anatomical_structure Neurology CD4 Antigens biology.protein Neurology (clinical) medicine.symptom business CD8 |
| Zdroj: | Journal of neuroimmunology. 35(1-3) |
| ISSN: | 0165-5728 |
| Popis: | The brains of pathogen-free autoimmune MRL/lpr, NZBWF1 and NZB mice were examined for central nervous system (CNS) inflammation in premoribund 8-week-old animals and at ages when active systemic lupus erythematosus (SLE) was present. CNS inflammation was observed only in MRL/lpr mice. Immunohistochemical studies of brains from young MRL/lpr mice found that infiltrates were composed primarily of CD4+ cells. Older MRL/lpr mice (22 and 26 weeks of age) had CD4+ cells predominantly, but CD8+ and B220+ cells were also present. Perivascular leakage of IgG was a prominent and unexpected finding in the MRL/lpr model. Congenic MRL/+ mice with late-onset autoimmunity had no inflammatory cells in brain tissue, and there was no perivascular staining with IgG or albumin. Our findings suggest that MRL/lpr mice are a useful model for studies of lupus-associated CNS inflammatory disease, and perivascular leakage may be a primary mechanism for entry of IgG into the brain. |
| Databáze: | OpenAIRE |
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