The S-2 oxygen atoms are essential for the pronounced fungitoxicity of the sulfur-rich natural product, dysoxysulfone

Autor:	Vanessa C. Stephenson, Richard Francis Langler, Charles R. Ross, Stephen J. Duffy, Stephen P. Fletcher, Heather Grace Morrison, Sharon Bewick, Erin M. O'Brien
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Green chemistry Reaction mechanism Natural product chemistry.chemical_element General Chemistry Crystal structure Medicinal chemistry Sulfur Catalysis chemistry.chemical_compound chemistry Biocatalysis Organic chemistry Macromolecule
Popis:	Synthesis and antifungal testing of 2,4,5,7,9-pentathiadecane 9,9-dioxide has established that the absence of oxygen atoms on S2 significantly attenuates fungitoxicity in accord with our earlier proposal. Attempts to convert that compound into dysoxysulfone led to the discovery of a novel oxidative conversion of unsymmetrical γ-sulfonyl disulfides into the corresponding symmetrical γ-sulfonyl disulfides.
Databáze:	OpenAIRE
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