Predicting the prognosis of undifferentiated pleomorphic soft tissue sarcoma: a 20‐year experience of 266 cases
| Autor: | John Slavin, Deborah May, Tim Spelman, Peter F. M. Choong, Domagoj A. Vodanovich |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Surgical margin Multivariate analysis medicine.medical_treatment Soft Tissue Neoplasms Histiocytoma Malignant Fibrous Gastroenterology Undifferentiated Pleomorphic Sarcoma Upper Extremity 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Adjuvant therapy Humans Neoplasm Metastasis Aged Retrospective Studies business.industry Soft tissue sarcoma Hazard ratio Margins of Excision Sarcoma General Medicine Middle Aged Prognosis medicine.disease Combined Modality Therapy Survival Rate Radiation therapy Lower Extremity Chemotherapy Adjuvant 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology Surgery Neoplasm Recurrence Local Positive Surgical Margin business |
| Zdroj: | ANZ Journal of Surgery. 89:1045-1050 |
| ISSN: | 1445-2197 1445-1433 |
| DOI: | 10.1111/ans.15348 |
| Popis: | BACKGROUND: Undifferentiated pleomorphic sarcoma (UPS) is a rare malignant tumour of mesenchymal origin, which was conceived following re-classification of malignant fibrous histiocytoma (MFH). The objective of this study is to determine prognostic factors for the outcome of UPS, following multi-modal treatment. METHODS: Data of UPS tumours from 1996 to 2016 were collected, totalling 266 unique UPS patients. Median follow-up was 7.8 years. All tumours were retrospectively analysed for prognostic factors of the disease, including local recurrence (LR) and metastatic disease (MD) at diagnosis, tumour size, grade, location and depth, patient age, adjuvant therapy and surgical margin. Overall survival (OS), post-treatment LR and metastatic-free survival were assessed as outcomes. RESULTS: The 5- and 10-year OS rates for all ages were 60% and 48%, respectively, with a median survival time of 10.1 years. Multivariate analysis revealed that the adverse prognostic factors associated with decreased OS were older age (P |
| Databáze: | OpenAIRE |
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