Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function
| Autor: | Shaohua Zhang, Zhongjun Dong, Xiaochu Shi, Mario-Ernesto Cruz-Munoz, André Veillette |
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| Rok vydání: | 2009 |
| Předmět: |
Natural Killer Cell Function
Gene Expression Profiling T-Lymphocytes SLAMF7 Immunology Biology Lymphocyte Activation Natural killer T cell Cell biology Killer Cells Natural Mice Inbred C57BL Mice Signaling lymphocytic activation molecule Animals Immunology and Allergy Receptors Immunologic Receptor Adaptor Proteins Signal Transducing Transcription Factors |
| Zdroj: | Nature Immunology. 10:297-305 |
| ISSN: | 1529-2916 1529-2908 |
| DOI: | 10.1038/ni.1693 |
| Popis: | CRACC is a self-associating member of the signaling lymphocytic activation molecule family that is expressed on cells of the immune system, including natural killer cells and activated T cells. Here we examine the function and mechanism of action of CRACC using several complementary approaches, including the generation of a CRACC-deficient mouse. Our results demonstrate that CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. CRACC was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins. |
| Databáze: | OpenAIRE |
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