Plasma levels of protease inhibitors in acute myeloid leukemia at the onset of the disease and during antiblastic therapy
| Autor: | Guido Grignani, Nadia Montani, M. Biancardi, Gabriella Gamba, Edoardo Ascari, Piermaria Fornasari |
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| Rok vydání: | 1980 |
| Předmět: |
Adult
Male Proteases Time Factors Myeloid Adolescent medicine.medical_treatment Disease Pharmacology hemic and lymphatic diseases medicine Humans Protease Inhibitors Aged Blood coagulation test Chemotherapy Protease Chemistry Myeloid leukemia Hematology Disseminated Intravascular Coagulation Middle Aged medicine.disease Leukemia Myeloid Acute Leukemia medicine.anatomical_structure Immunology Female Blood Coagulation Tests circulatory and respiratory physiology |
| Zdroj: | Thrombosis Research. 17:41-53 |
| ISSN: | 0049-3848 |
| Popis: | The levels of some plasma protease inhibitors during acute myeloid leukemia were investigated in two groups of patients: one with DIC and one without DIC. Our results indicate that plasma levels of α 1 -P.I. and α 1 -Achy, two specific inhibitors of leucocyte neutral proteases, were constantly high in all subjects and showed further increases after chemotherapy. α 2 -M, the third specific inhibitor, was generally low and did not seem to be univocally affected by the therapy. In patients with DIC a strong discrepancy between ATIII R: AG and ATIII activity was observed, probably indicating the presence of ATIII-thrombin complexes with partial inactivation of its biological function. |
| Databáze: | OpenAIRE |
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