Serum levels of galectin-3 in idiopathic inflammatory myopathies: a potential biomarker of disease activity
| Autor: | Eri Watanabe, Emiko Chiba, Takahisa Gono, Chihiro Terai, Kazunori Kato, Shigeru Kotake |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Galectin 3 Inflammation Severity of Illness Index Polymyositis Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Rheumatology Fibrosis otorhinolaryngologic diseases medicine Humans Pharmacology (medical) Lung Myositis Aged 030203 arthritis & rheumatology business.industry Interstitial lung disease Middle Aged Dermatomyositis medicine.disease 030104 developmental biology Galectin-3 Immunology Female Radiography Thoracic medicine.symptom Lung Diseases Interstitial business Biomarkers |
| Zdroj: | Rheumatology. 60:322-332 |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | Objectives Galectin-3 is involved in various biological activities, including immune activations and fibrosis. Idiopathic inflammatory myopathies (IIMs) are autoimmune diseases of unknown aetiology, often complicated by interstitial lung disease (ILD). The aim of this study was to evaluate the expression of galectin-3 in sera and tissues of patients with IIM and assess the associations of galectin-3 with patient characteristics and disease activity. Results Serum galectin-3 levels were significantly higher in IIM patients than in healthy controls. The serum galectin-3 levels positively correlated with serum levels of inflammatory markers and proinflammatory cytokines/chemokines and the Myositis Intention-to-Treat Activity Index. Stratification analysis revealed that patients with IIM-associated ILD (IIM-ILD) had significantly higher levels of serum galectin-3 than those without IIM-ILD. In addition, patients with acute/subacute interstitial pneumonia had significantly higher levels of serum galectin-3 than those with chronic interstitial pneumonia. Furthermore, serum galectin-3 levels in IIM-ILD patients correlated with the radiological assessments of parenchymal lung involvement and treatment response. Immunohistochemical analysis revealed that galectin-3 was expressed in inflammatory cells of myositis and dermatitis sections, whereas in ILD sections, galectin-3 was expressed in interstitial fibrosis and inflammatory cells. Conclusion Galectin-3 may be involved in the pathogenesis of inflammatory and fibrotic conditions in IIM and can serve as a potential biomarker of disease activity, especially in patients with IIM-ILD. |
| Databáze: | OpenAIRE |
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