Leukotriene Antagonist S 872419 A for Early-Phase Treatment of Chemical Burn in the Rabbit Eye
| Autor: | H.-U. Block, H G Struck, M Tost, H. Geiser, H J Mest |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Leukotrienes
Pathology medicine.medical_specialty genetic structures Neutrophils medicine.drug_class Eye disease Chemical burn Pharmacology Dinoprost Epithelium Aqueous Humor 03 medical and health sciences 0302 clinical medicine Burns Chemical medicine Animals Keratitis Wound Healing Leukotriene Lagomorpha biology Aqueous humour business.industry Antagonist General Medicine medicine.disease biology.organism_classification Receptor antagonist eye diseases Anterior Eye Segment Chemotaxis Leukocyte Eye Burns Ophthalmology 030221 ophthalmology & optometry Leukotriene Antagonists Rabbits sense organs Hydroxy Acids business 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Ophthalmology. 1:137-141 |
| ISSN: | 1724-6016 1120-6721 |
| DOI: | 10.1177/112067219100100306 |
| Popis: | S 872419 A, a specific receptor antagonist of peptide leukotrienes, was tested in the early-phase treatment of chemically burned eye (0.25 mol/l sodium hydroxide) of the rabbit. The drug was topically applied 5 times a day in a 1% solution, controls were the untreated opposite eye. Gross and microscopic investigations indicated that S 872419 A inhibits the inflammatory response of the chemically burned anterior eye segment. The parameters of healing considered (epithelial regeneration, corneal clouding and swelling, infiltration with polymorphonuclear leukocytes) suggest inhibition of lipoxygenase-mediated reactions in the tissue. PGF2 alpha levels were the same in aqueous humour of treated and untreated eyes. Further experiments with S 872419 A and other nonsteroidal drugs should improve the anti-inflammatory therapy of the chemically burned eye. |
| Databáze: | OpenAIRE |
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