Preparation of N-Arylpiperazines and Other N-Aryl Compounds from Aryl Bromides as Scaffolds of Bioactive Compounds

Autor:	Joan Basset, Maria Dolors Pujol, L. Ginet, Pere Constans, M. Romero, Y. Harrak
Rok vydání:	2007
Předmět:	Ligand Aryl Organic Chemistry General Medicine Biochemistry Toluene Pyrrole derivatives Catalysis Solvent chemistry.chemical_compound chemistry Drug Discovery Organic chemistry Weak base Palladium catalyst
Zdroj:	ChemInform. 38
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200701156
Popis:	Aryl bromides are coupled with N -compounds to give the corresponding arylamines in the presence of a palladium catalyst, a suitable ligand, and a weak base. The catalysts perform well for a large number of different starting material combinations at 100–150 °C with drops of toluene or without solvent, and with low catalyst levels (0.12 mol % Pd). The low catalyst amount makes the process environment friendly.
Databáze:	OpenAIRE
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