In Vitro Susceptibility of Berberine Combined with Antifungal Agents Against the Yeast Form of Talaromyces marneffei
| Autor: | Cunwei Cao, Rong Hu, Chun-Yang Huang, Yu-jiao Li, Xiu-ying Li, Justin Joseph, Gang Liang, Alex Andrianopoulos, Tian-min Li, Xiao-lu Luo, Yan-Qing Zheng, Hong Luo, Dongyan Zheng, Kai-Su Pan, Jing Guo, Le-min Wen |
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| Rok vydání: | 2019 |
| Předmět: |
Azoles
0301 basic medicine Antifungal Agents Berberine Talaromyces Itraconazole Veterinary (miscellaneous) 030106 microbiology Microbial Sensitivity Tests Applied Microbiology and Biotechnology Microbiology 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Caspofungin Amphotericin B medicine Mycosis Voriconazole Microbial Viability biology Drug Synergism biology.organism_classification medicine.disease chemistry Agronomy and Crop Science Fluconazole medicine.drug |
| Zdroj: | Mycopathologia. 184:295-301 |
| ISSN: | 1573-0832 0301-486X |
| Popis: | Talaromyces (Penicillium) marneffei can cause fatal disseminated infection in immunocompromised hosts. However, therapeutic strategies for the mycosis are limited. Reports of the other fungi suggest that berberine, a component of traditional herb, inhibitors interact with antifungal agents to improve the treatment outcomes. In the study, we evaluated the in vitro efficacy of berberine in combination with conventional antifungal agents against the pathogenic yeast form of T. marneffei. We demonstrate the synergistic effect of combination of berberine with fluconazole (52.38%), itraconazole (66.67%), voriconazole (71.43%), amphotericin B (71.43%) or caspofungin (52.38%) of T. marneffei strains, respectively. Time-kill curves confirmed the synergistic interaction, and no antagonistic was observed in all of the combinations. In conclusion, berberine could enhance the efficacy of conventional antifungal agents against the yeast form of T. marneffei in vitro. The results indicated berberine might have a potential role in combination therapy for talaromycosis. |
| Databáze: | OpenAIRE |
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