| Autor: |
Masato Tsutsui, Hajime Iizuka, Satoshi Kajita, Yoshiyuki Kusakabe, Akira Ohkawara, Shinobu Matsuo, Toshihiro Mizumoto, Takashi Yamauchi |
| Rok vydání: |
1984 |
| Předmět: |
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| Zdroj: |
The Journal of Dermatology. 11:111-116 |
| ISSN: |
0385-2407 |
| DOI: |
10.1111/j.1346-8138.1984.tb01451.x |
| Popis: |
Recent reports suggest there is a growth-associated fluctuation of calmodulin content in various tissues. Since psoriatic epidermis is one of the most proliferative epidermal tissues, we studied the calmodulin content of psoriatic involved and uninvolved epidermis. By measuring activation of the calmodulin-deficient phosphodiesterase purified from bovine brain, we assayed and compared the calmodulin activity in involved and uninvolved epidermis of seven psoriatic patients. Calmodulin purified from bovine brain was used as a standard. The mean calmodulin activity of the involved epidermis was 299 ± 149 (µg calmodulin activity/g.w.w. ±S.D.) or 9.6 ± 3.0 (µg calmodulin activity/mg protein). The mean calmodulin activity of the uninvolved epidermis was 251 ± 96 (µg calmodulin activity/g.w.w.) or 9.2 ± 2.9 (µg calmodulin activity/mg protein). These results indicate that psoriatic involved and uninvolved epidermis contains significant amounts of calmodulin, and that no marked differences exist in calmodulin content between these two areas. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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