Pathological roles of c‑Met in bladder cancer: Association with cyclooxygenase‑2, heme oxygenase‑1, vascular endothelial growth factor‑A and programmed death ligand�1
| Autor: | Yasuyoshi Miyata, Hideki Sakai, Asato Otsubo, Tomohiro Matsuo, Yuichiro Nakamura, Tsutomu Yuno, Yuta Mukae, Kensuke Mitsunari, Kyohei Araki, Kojiro Ohba |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research C-Met Receptor tyrosine kinase Metastasis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine cyclooxygenase?2 vascular endothelial growth factor-A c-Met biology phosphorylation Chemistry c?Met heme oxygenase-1 Articles medicine.disease vascular endothelial growth factor?A Heme oxygenase Vascular endothelial growth factor A 030104 developmental biology Oncology cyclooxygenase-2 programmed death ligand 1 030220 oncology & carcinogenesis Cancer cell Cancer research biology.protein bladder cancer Phosphorylation Hepatocyte growth factor heme oxygenase?1 medicine.drug |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | c-Met is a receptor tyrosine kinase that binds a specific ligand, namely hepatocyte growth factor (HGF). The HGF/c-Met system is important for malignant aggressiveness in various types of cancer, including bladder cancer (BC). However, although phosphorylation is the essential step required for biological activation of c-Met, pathological roles of phosphorylated c-Met at the clinical and molecular levels in patients with BC are not fully understood. In the present study, the expression levels of c-Met and the phosphorylation of two of its tyrosine residues (pY1234/pY1235 and pY1349) were immunohistochemically examined in 185 BC tissues. The associations between these expression levels and cancer cell invasion, metastasis, and cyclooxygenase-2 (COX-2), heme oxygenase-1 (HO-1), VEGF-A and programmed death ligand 1 (PD-L1) levels were investigated. c-Met was associated with muscle invasion (P=0.021), as well as the expression levels of HO-1 (P=0.028) and PD-L1 (P Oncology Letters, 20(1), pp.135-144; 2020 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|