Effect of Oxcarbazepine in the Treatment of Agitation and Aggression in Severe Dementia
| Autor: | Geir Selbæk, Knut Engedal, Inge C. Olsen, Milada Cvancarova, Oskar H. Sommer, Olav Aga |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Psychomotor agitation Cognitive Neuroscience Oxcarbazepine Double-Blind Method Alzheimer Disease mental disorders medicine Humans Dementia Vascular dementia Psychiatry Psychomotor Agitation Aged Aged 80 and over Inpatients Aggression Dementia Vascular Cognitive disorder Middle Aged medicine.disease Psychiatry and Mental health Carbamazepine Treatment Outcome Severe dementia Anticonvulsants Female Geriatrics and Gerontology Alzheimer's disease medicine.symptom Psychology medicine.drug |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 27:155-163 |
| ISSN: | 1421-9824 1420-8008 |
| Popis: | Background/Aims: To evaluate the efficacy of oxcarbazepine (OXC) in the treatment of agitation and aggression in patients with Alzheimer’s disease, vascular dementia or both. Methods: This is an 8-week, multicenter, randomized, double-blind, placebo-controlled trial carried out independently of the pharmaceutical industry. Changes in the agitation and aggression subscore of the Neuropsychiatric Inventory (NPI) were the primary outcomes. The secondary out- comes were the changes in the caregivers’ total burden scores (measured by the NPI) and changes in the Brief Agitation Rating Scale (BARS). Results: In total, 103 institutionalized patients at 35 sites were randomized to the trial. After 8 weeks, no statistically significant differences were found between the 2 groups for all outcomes. A trend was observed in favor of the OXC group in the reduction in the scores on the BARS (p = 0.07). Conclusion: This study found no significant effect of OXC in treatment of agitation and aggression in patients with dementia. |
| Databáze: | OpenAIRE |
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