The Comprehensive Antibiotic Resistance Database
| Autor: | Gerard D. Wright, Jonathan S O'Brien, Patricia L. Taylor, Irene Tang, Marie Yan, Arlene D. Sutherland, Lindsay Kalan, Wenliang Wang, Andrew C. Pawlowski, Mariya Morar, Maulik N. Thaker, Kirandeep Bhullar, Gianfranco De Pascale, Michael R. Mulvey, Marc J. Canova, Nicholas Waglechner, Fazmin Nizam, Marisa A. Azad, Andrew M. King, Kalinka Koteva, Linda Ejim, Peter Spanogiannopoulos, Andrew G. McArthur, Laura J. V. Piddock, Alison J. Baylay, Austin Yan, Tennison Yu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.drug_class
Ecology (disciplines) Antibiotics Genomics Computational biology Ontology (information science) Biology Genome User-Computer Interface Antibiotic resistance Anti-Infective Agents Mechanisms of Resistance Databases Genetic medicine Pharmacology (medical) Pharmacology Internet Base Sequence business.industry Computational Biology Drug Resistance Microbial Biotechnology Resistome Infectious Diseases Genes Bacterial business Genome Bacterial Antibiotic resistance genes |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 57:3348-3357 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.00419-13 |
| Popis: | The field of antibiotic drug discovery and the monitoring of new antibiotic resistance elements have yet to fully exploit the power of the genome revolution. Despite the fact that the first genomes sequenced of free living organisms were those of bacteria, there have been few specialized bioinformatic tools developed to mine the growing amount of genomic data associated with pathogens. In particular, there are few tools to study the genetics and genomics of antibiotic resistance and how it impacts bacterial populations, ecology, and the clinic. We have initiated development of such tools in the form of the Comprehensive Antibiotic Research Database (CARD; http://arpcard.mcmaster.ca ). The CARD integrates disparate molecular and sequence data, provides a unique organizing principle in the form of the Antibiotic Resistance Ontology (ARO), and can quickly identify putative antibiotic resistance genes in new unannotated genome sequences. This unique platform provides an informatic tool that bridges antibiotic resistance concerns in health care, agriculture, and the environment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|