Strategic Design and Fabrication of Nerve Guidance Conduits for Peripheral Nerve Regeneration
| Autor: | Sarker, Saman Naghieh, David J. Schreyer, Adam D. McInnes, Xiongbiao Chen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Computer science Nerve guidance conduit 02 engineering and technology Applied Microbiology and Biotechnology 03 medical and health sciences Peripheral nerve Peripheral Nerve Injuries medicine Animals Peripheral Nerves Cells Cultured Neurons Tissue Engineering Regeneration (biology) General Medicine Equipment Design 021001 nanoscience & nanotechnology Nanostructures Nerve Regeneration Rats 030104 developmental biology medicine.anatomical_structure Nanomedicine Molecular Medicine Axon guidance 0210 nano-technology Reinnervation Biomedical engineering |
| Zdroj: | Biotechnology journal. 13(7) |
| ISSN: | 1860-7314 |
| Popis: | Nerve guidance conduits (NGCs) have been drawing considerable attention as an aid to promote regeneration of injured axons across damaged peripheral nerves. Ideally, NGCs should include physical and topographic axon guidance cues embedded as part of their composition. Over the past decades, much progress has been made in the development of NGCs that promote directional axonal regrowth so as to repair severed nerves. This paper briefly reviews the recent designs and fabrication techniques of NGCs for peripheral nerve regeneration. Studies associated with versatile design and preparation of NGCs fabricated with either conventional or rapid prototyping (RP) techniques have been examined and reviewed. The effect of topographic features of the filler material as well as porous structure of NGCs on axonal regeneration has also been examined from the previous studies. While such strategies as macroscale channels, lumen size, groove geometry, use of hydrogel/matrix, and unidirectional freeze-dried surface are seen to promote nerve regeneration, shortcomings such as axonal dispersion and wrong target reinnervation still remain unsolved. On this basis, future research directions are identified and discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text