Effects of chronic low-dose exposure to ionizing radiation on physician microvascular structure revealed by nail fold capillaroscopy
| Autor: | Karine Champion, Pascal Wild, Michel Grzebyk, Hélène Thiel, Raffaele Pennarola, Pascal Cohen, Christine Gauron, Caroline Menez, Dominique Choudat, Anne-Sophie Tellart |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Biophysics Cumulative Exposure Asymptomatic 030218 nuclear medicine & medical imaging Ionizing radiation Microscopic Angioscopy 03 medical and health sciences 0302 clinical medicine Occupational Exposure Physicians Epidemiology medicine Humans General Environmental Science Retrospective Studies Radiation Dose-Response Relationship Drug business.industry Confounding Low dose Middle Aged Nail fold 030220 oncology & carcinogenesis Asymptomatic Diseases Microvessels Female Radiology medicine.symptom Abnormality business |
| Zdroj: | Radiation and environmental biophysics. 55(1) |
| ISSN: | 1432-2099 |
| Popis: | The aim of this study was to assess the long-term asymptomatic effects of low-dose radiation on microvascular structure among interventional physicians, whose hands are exposed to ionizing radiation during daily practice. The study, approved by the national ethics committee, included 186 radiation-exposed (surgeons, cardiologists, radiologists) and 35 unexposed physicians, all of whom had provided written consent. The subjects completed a questionnaire describing their current and past daily practice, from which tentative estimates of current and cumulative radiation exposure estimates were computed. Subject dermal microcirculation state was assessed by capillaroscopy of the nail fold of eight fingers (thumbs excluded) based on photographs. Two quantitative scores characterizing extravasation and morphological abnormalities based on seven semiquantitative indices were obtained from post hoc coding of the photographs by five capillaroscopists. These evaluations were randomized and blind to the exposure. The effect of the radiation exposure on both abnormality scores was modelled using multilevel proportional odds regression adjusted for potential confounders. The proportion of physicians for which the most frequent act is close to the radiation source was highest among surgeons, but with fewer weekly acts. The median duration of exposure was highest among radiologists and cardiologists. No exposure effect could be detected on the extravasation score. The morphological anomaly score increased significantly with duration of exposure and estimated cumulative exposure among surgeons and interventional radiologists, unlike cardiologists among whom no effect could be detected. It is concluded that the shown effects of chronic low-dose exposure to ionizing radiation on physician microvascular structure reveal the importance of increased exposure monitoring and prevention. |
| Databáze: | OpenAIRE |
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