Evidence of autoimmunity in chronic periaortitis: a prospective study
| Autor: | Lucio Manenti, Stefania Ferretti, Domenico Corradi, Giovanni Garini, Augusto Vaglio, Carlo Buzio |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Anti-nuclear antibody Autoimmunity Blood Sedimentation Retroperitoneal fibrosis Autoimmune thyroiditis medicine Humans Prospective Studies Fibrinoid necrosis Idiopathic Retroperitoneal Fibrosis Aorta Aged Autoantibodies Anti-neutrophil cytoplasmic antibody Aged 80 and over Vascular disease business.industry Retroperitoneal Fibrosis General Medicine Middle Aged medicine.disease C-Reactive Protein Female medicine.symptom business Vasculitis |
| Zdroj: | The American Journal of Medicine. 114:454-462 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/s0002-9343(03)00056-1 |
| Popis: | Background Chronic periaortitis includes idiopathic retroperitoneal fibrosis, inflammatory aneurysms of the abdominal aorta, and perianeurysmal retroperitoneal fibrosis. It is considered to be due to advanced atherosclerosis, but is often associated with systemic autoimmune disorders. Methods We studied 16 consecutive patients who were diagnosed with chronic periaortitis by computed tomography. Each patient underwent a physical examination, routine laboratory tests, measurement of autoantibodies, thyroid echotomography, and chest radiography. Aortic wall or periaortic retroperitoneal samples from 9 patients who underwent surgery were available for histologic examination and immunohistochemical characterization of the inflammatory infiltrate. Results Twelve patients had constitutional symptoms, 14 had an elevated erythrocyte sedimentation rate, and 13 had an elevated C-reactive protein level. Antinuclear antibodies were positive in 10 patients. Three patients had autoimmune thyroiditis, and 1 had seropositive rheumatoid arthritis. Antineutrophil cytoplasmic antibodies were positive in 3 patients who presented with rapidly progressive renal failure. Pathologic examination of the aortic and periaortic specimens revealed moderate to severe inflammatory infiltration, mainly consisting of B cells and CD4 + T cells. Vasculitis with fibrinoid necrosis involving the aortic vasa vasorum and the small and medium retroperitoneal vessels was found in seven of the nine histologic samples. Conclusion These clinical and pathologic features support the hypothesis that, at least in some patients, chronic periaortitis is a systemic autoimmune disease, perhaps involving a vasculitic process of small and medium vessels. |
| Databáze: | OpenAIRE |
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