Computational fluid dynamics of the right atrium: Assessment of modelling criteria for the evaluation of dialysis catheters

Autor: Daniel M. Espino, David G. Owen, Duncan E.T. Shepherd, Shuang Qian, Diana C. de Oliveira, Naomi C. Green
Rok vydání: 2020
Předmět:
Models
Anatomic
Physiology
medicine.medical_treatment
Hemodynamics
Catheters
Indwelling
Blood Flow
Medicine and Health Sciences
Central Venous Catheters
Shear Stresses
Flow Rate
Multidisciplinary
Physics
Models
Cardiovascular
Classical Mechanics
Equipment Design
Hematology
Body Fluids
Catheter
Blood
Nephrology
Physical Sciences
Medicine
Engineering and Technology
Mechanical Stress
Anatomy
Blood Flow Velocity
Research Article
Biotechnology
Catheterization
Central Venous
Catheters
Science
Flow (psychology)
Bioengineering
Fluid Mechanics
Computational fluid dynamics
Continuum Mechanics
Medical Dialysis
Shear stress
medicine
Humans
Computer Simulation
Platelet activation
Heart Atria
Fluid Flow
Dialysis
business.industry
Biology and Life Sciences
Fluid Dynamics
Vorticity
Hydrodynamics
Medical Devices and Equipment
Stress
Mechanical
business
Biomedical engineering
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0247438 (2021)
ISSN: 1932-6203
Popis: Central venous catheters are widely used in haemodialysis therapy, having to respect design requirements for appropriate performance. These are placed within the right atrium (RA); however, there is no prior computational study assessing different catheter designs while mimicking their native environment. Here, a computational fluid dynamics model of the RA, based on realistic geometry and transient physiological boundary conditions, was developed and validated. Symmetric, split and step catheter designs were virtually placed in the RA and their performance was evaluated by: assessing their interaction with the RA haemodynamic environment through prediction of flow vorticity and wall shear stress (WSS) magnitudes (1); and quantifying recirculation and tip shear stress (2). Haemodynamic predictions from our RA model showed good agreement with the literature. Catheter placement in the RA increased average vorticity, which could indicate alterations of normal blood flow, and altered WSS magnitudes and distribution, which could indicate changes in tissue mechanical properties. All designs had recirculation and elevated shear stress values, which can induce platelet activation and subsequently thrombosis. The symmetric design, however, had the lowest associated values (best performance), while step design catheters working in reverse mode were associated with worsened performance. Different tip placements also impacted on catheter performance. Our findings suggest that using a realistically anatomical RA model to study catheter performance and interaction with the haemodynamic environment is crucial, and that care needs to be given to correct tip placement within the RA for improved recirculation percentages and diminished shear stress values.
Databáze: OpenAIRE
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