Brain glutamate and γ-aminobutyrate (GABA) metabolism in thiamin-deficient rats
| Autor: | V Ankoma-Sey, David A. Bender, W F Coulson, M G Page |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Central nervous system Medicine (miscellaneous) Biology gamma-Aminobutyric acid Glutamates Internal medicine medicine Animals gamma-Aminobutyric Acid Nutrition and Dietetics Glutamate receptor Brain Thiamine Deficiency food and beverages Rats Inbred Strains Metabolism Glutamic acid Rats B vitamins Endocrinology medicine.anatomical_structure Thiamine human activities Flux (metabolism) medicine.drug |
| Zdroj: | British Journal of Nutrition. 62:245-253 |
| ISSN: | 1475-2662 0007-1145 |
| Popis: | The brain metabolism of glutamate and γ-aminobutyrate (GABA) was investigated in thiamin-deficient and pair-fed control rats, in order to determine whether the GABA shunt may provide an important alternative to 2-oxo-glutarate dehydrogenase (EC1.2.4.2) in energy-yielding metabolism in thiamin deficiency. Brains from thiamin-deficient animals contained less glutamate, 2-oxo-glutarate and GABA than those from control animals. The brain content of ATP was unaffected by thiamin deficiency. After intracerebroventricular injection of [14C]glutamate, the specific radioactivity of GABA in the brains from deficient animals was 45–50% higher than that in controls, suggesting a considerable increase in the metabolic flux through the GABA shunt in thiamin deficiency. Brain GABA showed a marked circumannual variation, with a peak in mid-summer and a minimum value in mid-winter. |
| Databáze: | OpenAIRE |
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