Assessment of intestinal permeability and orocecal transit time in patients with systemic sclerosis: analysis of relationships with epidemiologic and clinical parameters
Autor: | Mario Secondulfo, G. Caravelli, L. Caserta, C. Naclerio, Giovanna Cuomo, Gabriele Valentini, Salvatore D'Angelo, Gabriele Riegler, Laura de Magistris, Romano Carratù |
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Rok vydání: | 2002 |
Předmět: |
Adult
Male medicine.medical_specialty Systemic disease Immunology Gastroenterology Severity of Illness Index Permeability Rheumatology Internal medicine Immunopathology Severity of illness Epidemiology medicine Immunology and Allergy Humans Intestinal Mucosa skin and connective tissue diseases Gastrointestinal Transit Aged Autoantibodies Intestinal permeability Scleroderma Systemic integumentary system business.industry Case-control study Nuclear Proteins Middle Aged medicine.disease Connective tissue disease Intestines Diagnostic Techniques Digestive System Breath Tests DNA Topoisomerases Type I Case-Control Studies Female business |
Zdroj: | Rheumatology international. 23(5) |
ISSN: | 0172-8172 |
Popis: | The aim of this study was to assess intestinal permeability (IP) in patients with systemic sclerosis (SSc) and to relate the results with general disease activity and gastrointestinal involvement.Twenty-eight females and four males were studied. Patients with severe gastrointestinal involvement were excluded. Thirty-three healthy volunteers served as controls. Intestinal permeability was assessed by means of the orally administered cellobiose/mannitol sugar (Ce/Ma) test. Intestinal transit time (ITT) was investigated with the H2-lactulose breath test.The mean value of IP in 32 SSc patients was significantly higher than in 33 controls ( P0.05), although it fell within the normal range. Eleven patients showed abnormally high individual IP values (0.028) that significantly correlated to disease duration ( r=0.73). Altered IP was associated with the higher but not statistically relevant presence of anti-Scl70 antibodies (9/11) and to more severe gastrointestinal involvement. More than half of the SSc patients showed slower orocecal transit times on the H2 breath test. In particular, delayed ITT was observed in 60% of patients with increased IP and in all patients with moderate gastrointestinal involvement according to the scleroderma severity scale.Intestinal permeability was altered in 11/32 SSc patients. Correlations between increased IP and duration of disease and degree of gastrointestinal involvement appear to support the hypothesis of secondary involvement of the intestinal barrier, and the presence of anti-Scl70 antibodies in 82% of the patients with higher IP clearly reinforces the hypothesis of an altered immune response in these subjects. |
Databáze: | OpenAIRE |
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