Effect of Hydroxyurea on Immature Reticulocyte Fraction in Sickle Cell Anemia
| Autor: | Robert Bagdasaryan, Karen Quillen, Dongsheng Xu, Fernando Chaves, Lewis Glasser |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Reticulocytes Adolescent Clinical Biochemistry Cell Stimulation Anemia Sickle Cell Reticulocyte Count alpha-Thalassemia Reticulocyte Antisickling Agents Internal medicine medicine Humans Hydroxyurea Erythropoiesis Child Alpha globulin Arc (protein) business.industry Biochemistry (medical) Hematology medicine.disease Sickle cell anemia Hemolysis Endocrinology medicine.anatomical_structure Case-Control Studies Female Bone marrow business |
| Zdroj: | Laboratory Hematology. 13:93-97 |
| ISSN: | 1080-2924 |
| DOI: | 10.1532/lh96.07008 |
| Popis: | Immature reticulocyte fraction (IRF) is a good indicator of bone marrow erythropoiesis in response to hemolysis or tissue hypoxia and is markedly increased in sickle cell disease (SS). We compared IRF changes in SS patients with those who were treated with hydroxyurea (SS-HU), and those who had concurrent alpha globin gene deletion (SS-(- deletion). Forty-two patients including 16 SS, 16 SS-HU, and 10 SS-alpha-deletion patients were studied. Significant decreases (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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