Effects of Pinus brutia bark extract and Pycnogenol® in a rat model of carrageenan induced inflammation
| Autor: | G. Elgin, I. Ince, Ozlem Yesil-Celiktas, N.U. Karabay-Yavasoglu |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Carrageenan induced inflammation Rat model Anti-Inflammatory Agents Pharmaceutical Science Carrageenan Catechin chemistry.chemical_compound Pinus brutia Drug Discovery medicine Animals Edema Rats Wistar Flavonoids Inflammation Pharmacology Dose-Response Relationship Drug biology Traditional medicine Plant Extracts Pinus biology.organism_classification Rats Disease Models Animal Complementary and alternative medicine chemistry visual_art Toxicity Plant Bark visual_art.visual_art_medium Molecular Medicine Quercetin Bark Swelling medicine.symptom Phytotherapy Paw edema |
| Zdroj: | Phytomedicine. 16:1101-1104 |
| ISSN: | 0944-7113 |
| DOI: | 10.1016/j.phymed.2009.05.004 |
| Popis: | The present study was conducted to explore the anti-inflammatory activities of Pinus brutia bark extract and Pycnogenol in a rat model of carrageenan-induced inflammation. Firstly, the compositions of both samples were determined using HPLC. Then, carrageenan-induced paw edema was used to assess anti-inflammatory activity in mice. Paw volume was measured before and 1, 2, 3, 4, 5 and 6h after the injection of carrageenan. Intraperitoneal administration of both the extract and Pycnogenol inhibited paw swelling dose-dependently at 2, 3, 4, 5 and 6h after carrageenan injection. Both samples exhibited significant anti-inflammatory activities at doses of 75 and 100 mg/kg body wt. between 2 and 4 hours after administration (p0.05), respectively. Additionally, P. brutia bark extract showed significantly better activity at doses of 75 and 100mg/kg body wt. than indomethacine at the dose of 10mg/kg body wt. (p0.05). No acute toxicity was identified in intraplantar injection of the extract at a dose of 2000 mg/kg body wt.. Therefore, P. brutia bark extract possessing 3.3-fold more total catechins and 9.8-fold more taxifolin than Pycnogenol can be utilized as an anti-inflammatory agent. |
| Databáze: | OpenAIRE |
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