Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases
| Autor: | Joice Neves Reis, Jailton Azevedo, Francine Chenou, Helena Ferreira Leal, Marilda Souza Goncalves |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Population Bacterial meningitis 030204 cardiovascular system & hematology medicine.disease_cause Haemophilus influenzae 03 medical and health sciences 0302 clinical medicine Internal medicine Streptococcus pneumoniae medicine Immunology and Allergy H. influenzae education Stroke S. Pneumoniae education.field_of_study business.industry lcsh:RC633-647.5 Medical record Hematology lcsh:Diseases of the blood and blood-forming organs medicine.disease Sickle cell anemia Heart failure Original Article business Meningitis 030215 immunology |
| Zdroj: | Hematology, Transfusion and Cell Therapy, Vol 42, Iss 2, Pp 139-144 (2020) Hematology, Transfusion and Cell Therapy |
| ISSN: | 2531-1379 |
| Popis: | Sickle cell anemia (SCA) is a common genetic blood disorder, affecting millions worldwide. According to current evidence, individuals with SCA have more than 300 times greater risk to develop bacterial meningitis (BM) than the general population. Herein we have described the characteristics of a series of BM cases in SCA patients in Salvador, Brazil, during 13 years of hospital-based surveillance. Data on clinical presentation, laboratory parameters and outcomes were collected retrospectively by reviewing medical records. From 1999 to 2011, ten SCA patients were identified among the 2511 cases of BM (10/2511; 0.40%). These patients were more likely to be male (90%) and to be younger (median age 8.5 years). The causative agents were Streptococcus pneumoniae (n = 5) and Haemophilus influenzae (n = 1). The most frequent pneumococcal serotypes were 23 F (2 cases), 14, 18 F, 23B (one case each). Common medical complications were stroke (n = 3); heart failure (n = 2), respiratory problems (n = 2), renal dysfunctions (n = 2) and leg ulcers (n = 1). This study highlights the importance of S. pneumoniae as a causative agent of meningitis in individuals with SCA and shows the diversity of comorbidities associated with this condition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|