Flow cytometric analysis of cerebrospinal fluid improves detection of leukaemic blasts in infants with acute lymphoblastic leukaemia
| Autor: | Birgitte Lausen, Aina Ulvmoen, Britt-Marie Frost, Jonas Abrahamsson, Hanne Vibeke Marquart, Kjeld Schmiegelow, Arja Harila-Saari, Signe Modvig, Dorota Wojcik, Mette Levinsen, Birgitte Klug Albertsen, Jouni Pesola, Mervi Taskinen, Maria Thastrup, Marianne Hoffmann |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Pathology medicine.medical_specialty Central nervous system cerebrospinal fluid Flow cytometry Metastasis 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Leukemic Infiltration Recurrence Antineoplastic Combined Chemotherapy Protocols medicine Humans metastasis Childhood all Cerebrospinal Fluid childhood medicine.diagnostic_test business.industry flow cytometry Infant Newborn Infant Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Flow Cytometry central nervous system Csf flow 3. Good health medicine.anatomical_structure 030220 oncology & carcinogenesis Neoplastic Stem Cells Lymphoblastic leukaemia Female business ALL Cytometry 030215 immunology Follow-Up Studies |
| Zdroj: | Thastrup, M, Marquart, H V, Levinsen, M, Modvig, S, Abrahamsson, J, Albertsen, B K, Frost, B M, Harila-Saari, A, Pesola, J, Ulvmoen, A, Wojcik, D M, Taskinen, M, Hoffmann, M, Lausen, B, Schmiegelow, K & the Nordic Society of Paediatric Haematology, Oncology (NOPHO) 2021, ' Flow cytometric analysis of cerebrospinal fluid improves detection of leukaemic blasts in infants with acute lymphoblastic leukaemia ', British Journal of Haematology, vol. 195, no. 1, pp. 119-122 . https://doi.org/10.1111/bjh.17769 |
| DOI: | 10.1111/bjh.17769 |
| Popis: | Infants with acute lymphoblastic leukaemia (ALL) have a high frequency of central nervous system (CNS) involvement. Flow cytometric analysis of cerebrospinal fluid (CSF) was recently demonstrated to be a sensitive method for detecting CNS involvement in childhood ALL. In the present study, CSF from 14 infants was collected at routine lumbar punctures and analysed by multicolour flow cytometry. At initial diagnosis, leukaemic blasts were detected in CSF by flow cytometry in 11 patients (78·6%) compared to seven patients (50%) by cytospin. Larger studies are needed to determine if CSF flow cytometry has prognostic value in infant ALL. |
| Databáze: | OpenAIRE |
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