Can previous associations of single nucleotide polymorphisms in the tlr2, nod1, cxcr5, and il10 genes in the susceptibility to and severity of chlamydia trachomatis infections be confirmed?
| Autor: | Caroline J. Bax, Nicole H. T. M. Dukers-Muijrers, Marianne A B van der Sande, Christian J. P. A. Hoebe, Jelmer B. Jukema, Henry J. C. de Vries, Sander Ouburg, Bernice M Hoenderboom, Servaas A. Morré, Birgit H B van Benthem |
|---|---|
| Přispěvatelé: | VU University medical center, Medical Microbiology and Infection Prevention, Dermatology, Obstetrics and gynaecology, AII - Infectious diseases, APH - Methodology, Obstetrics and Gynaecology, Sociale Geneeskunde, RS: CAPHRI - R4 - Health Inequities and Societal Participation, Med Microbiol, Infect Dis & Infect Prev, Health promotion, RS: GROW - R4 - Reproductive and Perinatal Medicine, Institute for Public Health Genomics |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty lcsh:Medicine SNP Single-nucleotide polymorphism Chlamydia trachomatis medicine.disease_cause Gastroenterology Article Severity single nucleotide polymorphism susceptibility severity Internal medicine Genetic variation Immunology and Allergy Medicine Molecular Biology Gene General Immunology and Microbiology Ectopic pregnancy business.industry lcsh:R Tubal factor infertility medicine.disease Single nucleotide polymorphism Interleukin 10 Infectious Diseases Susceptibility business |
| Zdroj: | Pathogens, 10(1):48, 1-16. MDPI AG Pathogens (Basel, Switzerland), 10(1):48, 1-16. MDPI AG Pathogens; Volume 10; Issue 1; Pages: 48 Pathogens Pathogens, 10(1):48. MDPI Pathogens, Vol 10, Iss 48, p 48 (2021) Jukema, J B, Hoenderboom, B M, van Benthem, B H B, van der Sande, M A B, de Vries, H J C, Hoebe, C J P A, Dukers-Muijrers, N H T M, Bax, C J, Morré, S A & Ouburg, S 2021, ' Can previous associations of single nucleotide polymorphisms in the tlr2, nod1, cxcr5, and il10 genes in the susceptibility to and severity of chlamydia trachomatis infections be confirmed? ', Pathogens, vol. 10, no. 1, 48, pp. 1-16 . https://doi.org/10.3390/pathogens10010048 |
| ISSN: | 2076-0817 |
| DOI: | 10.3390/pathogens10010048 |
| Popis: | Clear inter-individual differences exist in the response to C. trachomatis (CT) infections and reproductive tract complications in women. Host genetic variation like single nucleotide polymorphisms (SNPs) have been associated with differences in response to CT infection, and SNPs might be used as a genetic component in a tubal-pathology predicting algorithm. Our aim was to confirm the role of four genes by investigating proven associated SNPs in the susceptibility and severity of a CT infection. A total of 1201 women from five cohorts were genotyped and analyzed for TLR2 + 2477 G > A, NOD1 + 32656 T −> GG, CXCR5 + 10950 T > C, and IL10 − 1082 A > G. Results confirmed that NOD1 + 32656 T −>GG was associated with an increased risk of a symptomatic CT infection (OR: 1.9, 95%CI: 1.1–3.4, p = 0.02), but we did not observe an association with late complications. IL10 − 1082 A > G appeared to increase the risk of late complications (i.e., ectopic pregnancy/tubal factor infertility) following a CT infection (OR = 2.8, 95%CI: 1.1–7.1, p = 0.02). Other associations were not found. Confirmatory studies are important, and large cohorts are warranted to further investigate SNPs’ role in the susceptibility and severity of a CT infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|