Effect of food intake on the activity of liver enzymes in partially hepatectomized rats treated with tumor necrosis factor
| Autor: | Athanasios Theologides, H S Beyer, Walid G. Yasmineh, Janelle I. Caspers |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Necrosis medicine.medical_treatment Biology Biochemistry Rats Sprague-Dawley Eating Internal medicine medicine Animals Hepatectomy Pharmacology chemistry.chemical_classification Tumor Necrosis Factor-alpha digestive oral and skin physiology Gluconeogenesis Pathophysiology Liver regeneration Recombinant Proteins Liver Regeneration Rats Endocrinology Enzyme chemistry Liver Tumor necrosis factor alpha medicine.symptom Phosphoenolpyruvate carboxykinase |
| Zdroj: | Biochemical pharmacology. 50(8) |
| ISSN: | 0006-2952 |
| Popis: | After partial hepatectomy (PHx), there are significant changes in the activity of a number of enzymes in the regenerating rat liver. Administration of low doses of recombinant human tumor necrosis factor-alpha (rHu-TNF) to normal rats induces similar changes in some of the enzymes but not in others. Because certain observations suggest that TNF may play a dominant role in liver regeneration, we speculated that the discrepancies in enzyme activities may be due to the decrease in food intake caused by PHx. Accordingly, the activities of eleven liver enzymes of 70% PHx rats additionally treated i.p. with rHu-TNF (20-50 micrograms/kg/day for 3-4 days) were compared with those of (i) PHx controls fed ad lib., and (ii) PHx controls pair-fed the same amount of food. When pair-fed controls were used, the discrepancies in the activities of the enzymes that are affected by fasting tended to disappear, suggesting that the decrease in the food intake was responsible for the differences. |
| Databáze: | OpenAIRE |
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