Importance of FAS-1377, FAS-670, and FASL-844 Polymorphisms in Tumor Onset, Progression, and Pigment Phenotypes of Swedish Patients With Melanoma: A Case-Control Analysis
| Autor: | Xiao-Feng Sun, Hong Zhang, Ingrid Synnerstad, Inger Rosdahl |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Genetic Markers Male Cancer Research Fas Ligand Protein Skin Neoplasms Human skin Fas ligand medicine Humans Genetic Predisposition to Disease fas Receptor Melanoma neoplasms Sweden Biologic marker Polymorphism Genetic business.industry Middle Aged medicine.disease Phenotype Oncology Case-Control Studies Immunology Disease Progression Sunlight Case control analysis Cancer research Female business |
| Zdroj: | The Cancer Journal. 13:233-237 |
| ISSN: | 1528-9117 |
| DOI: | 10.1097/ppo.0b013e318046f214 |
| Popis: | Human skin melanoma at later stages usually has an extremely poor prognosis. It is of importance to search for biologic markers to identify and monitor individuals at risk for melanoma for early diagnosis and to avoid tumor progression. The FAS gene and its natural ligand (FASL) gene initiate the death signal cascade, playing a central role in the apoptotic signaling pathway and tumor growth and metastasis.In this study, we analyzed polymorphisms in 229 patients with melanoma and 351 age- and gender-matched tumor-free individuals. Genomic DNAs were isolated from mononuclear cells in peripheral vein blood, and the polymorphisms were examined with polymerase chain reaction-restriction fragment length polymorphism techniques. Frequency in distribution of the polymorphisms was compared between the patients with melanoma and the healthy control subjects, and associations with patients' pigment phenotypes, age at diagnosis, and melanoma characteristics were analyzed.The FAS-1377, FAS-670, and FASL-844 polymorphisms were not found to be markers of melanoma risk (P0.05). In patients with melanoma, frequencies of the FAS-1377, FAS-670, and FASL-844 polymorphisms were different between the patients aged50 andor =50 years (Por = 0.025, Por = 0.025, and Por = 0.01). Moreover, the FAS-670 polymorphism correlated with tumor Breslow thickness (Por = 0.01) and Clark level (Por = 0.001) and was associated with tumors developing in sun-exposed locations (Por = 0.001). FAS and FASL were not markers for melanoma risk but might be important in the development and progression of sun-induced melanoma independently of skin type. |
| Databáze: | OpenAIRE |
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