Cocaine-induced Psychosis and Brain-derived Neurothrophic Factor in Patients with Cocaine Dependence: Report of Two Cases
| Autor: | Miguel Casas, Carlos Roncero, Margarida Corominas-Roso, Raúl Felipe Palma-Álvarez, Begoña Gonzalvo, Carmen Barral, Lara Grau-López, Elena Ros-Cucurull |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Psychosis medicine.medical_specialty media_common.quotation_subject Case Report Brain-derived neurotrophic factor Cocaine dependence 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Neurotrophic factors Internal medicine medicine Pharmacology (medical) In patient Adverse effect Psychiatry media_common Induced psychosis business.industry Addiction medicine.disease 030227 psychiatry Psychiatry and Mental health Biological marker nervous system business 030217 neurology & neurosurgery Cocaine-induced psychosis |
| Zdroj: | Clinical Psychopharmacology and Neuroscience Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona |
| ISSN: | 2093-4327 1738-1088 |
| Popis: | Brain-derived neurotrophic factor (BDNF) is linked to numerous brain functions. In addition, BDNF alterations contribute to neurological, mental, and addictive disorders. Cocaine dependence has received much attention recently due to its prevalence and psychological effects. Symptoms of psychosis are one of the most serious adverse events precipitated by cocaine use. It is particularly important to identify patients at risk of developing cocaine-induced psychosis (CIP). We described two cases of patients with cocaine dependence who presented with CIP and had changes in their BDNF levels during the psychotic episode. BDNF levels were initially low in both patients, and then decreased by more than 50% in association with CIP. The relationship between BDNF and psychosis is described in the literature. These cases revealed that BDNF levels decreased during a CIP episode and, thus, it is necessary to investigate BDNF and its relationship with CIP further. |
| Databáze: | OpenAIRE |
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