Trypanocidal effects of catecholamines and indolealkylamines
| Autor: | D. H. Molyneux, O. A. Owolabi, C. Wilson, V. W. Pentreath |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Serotonin
animal structures Dopamine medicine.medical_treatment Trypanosoma brucei brucei 030231 tropical medicine Intraperitoneal injection Trypanosoma brucei Cell Line Hydroxydopamines Mice 03 medical and health sciences chemistry.chemical_compound Catecholamines 0302 clinical medicine In vivo 030225 pediatrics medicine Animals Dihydroxytryptamines Fibroblast Hydrogen peroxide Mice Inbred C3H biology biology.organism_classification In vitro Trypanosomiasis African Infectious Diseases medicine.anatomical_structure nervous system Biochemistry chemistry Cell culture Parasitology Oxidation-Reduction medicine.drug |
| Zdroj: | Annals of Tropical Medicine & Parasitology. 84:127-131 |
| ISSN: | 1364-8594 0003-4983 |
| DOI: | 10.1080/00034983.1990.11812445 |
| Popis: | Catecholamines, indolealkylamines and their analogues are oxidized at neutral or alkaline pH, producing hydrogen peroxide, quinones and free radicals. Several of these amines were tested for trypanocidal effects on Trypanosoma brucei, which possess a well-documented vulnerability to such oxidation products. Dopamine, 5-hydroxydopamine (5-OHDA), 6-hydroxydopamine (6-OHDA), 5-hydroxytryptamine (5-HT), 5,6-dihydroxytryptamine (5,6-DHT) and 5,7-dihydroxytryptamine (5,7-DHT) killed the parasites in vitro, using a fibroblast feeder layer cell culture system, in four to 48 hours at concentrations of 10(-5)-10(-7) M. The 5-OHDA, 6-OHDA, 5,6-DHT and 5,7-DHT were also effective in vivo when tested by intraperitoneal injection of infected mice. |
| Databáze: | OpenAIRE |
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