PIAS genes as disease markers in bipolar disorder
| Autor: | Iman Azari, Mohammad Taheri, Vahid Kholghi Oskoei, Soudeh Ghafouri-Fard, Arezou Sayad |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Bipolar Disorder Adolescent Biochemistry stat Pathogenesis Young Adult 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Internal medicine Humans Medicine Genetic Predisposition to Disease Bipolar disorder Poly-ADP-Ribose Binding Proteins Molecular Biology Gene Transcription factor business.industry Area under the curve Cell Biology Middle Aged medicine.disease Protein Inhibitors of Activated STAT Diagnostic and Statistical Manual of Mental Disorders 030104 developmental biology ROC Curve 030220 oncology & carcinogenesis Small Ubiquitin-Related Modifier Proteins STAT protein Female business Biomarkers Molecular Chaperones |
| Zdroj: | Journal of Cellular Biochemistry. 120:12937-12942 |
| ISSN: | 1097-4644 0730-2312 |
| DOI: | 10.1002/jcb.28564 |
| Popis: | The protein inhibitors of activated STAT (PIAS) are involved in regulation of many transcription factors and signaling pathways that contribute to the pathogenesis of bipolar disease (BD). In the current study, we evaluated the expression of four PIAS genes (PIAS1-4) in peripheral blood of BD patients and healthy subjects to explore their contribution in the pathogenesis of BD and their suitability as peripheral biomarkers for this disorder. All PIAS genes were significantly upregulated in total BD patients compared with total controls. The sex-based analysis confirmed upregulation of PIAS1-4 genes in male BD patients compared with male controls (P < 0.001). However, PIAS1 was significantly downregulated in female patients compared with female controls (P = 0.02). Expression levels of other PIAS genes were not significantly different between female patients and female controls. There were no significant correlations between expression levels of PIAS genes and any of the clinical data of study participants after adjustment of the effects of the sex. On the basis of the area under the curve (AUC) values in receiver operating characteristic curves, PIAS4 had the best performance in the differentiation of disease status between study participants (AUC = 0.81). PIAS3 and PIAS4 genes had the best sensitivity and specificity values, respectively. Combination of expression levels of four genes resulted in the improvement of diagnostic power (AUC = 0.82). The current data implies the role of PIAS genes in the pathogenesis of BD and denotes their suitability as peripheral markers for this disorder. |
| Databáze: | OpenAIRE |
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