Amyloid-beta42 plasma levels are elevated in amnestic mild cognitive impairment
| Autor: | Valeria Pollero, Roberta Borghi, Patrizio Odetti, Michele Fornaro, Matteo Pardini, Sergio Cammarata, Luca Giliberto, Massimo Tabaton, Cristina Novello, Antonella Vitali, Carlo Caltagirone, Laura Bracco, Paola Bossù |
|---|---|
| Přispěvatelé: | Cammarata, Sergio, Borghi, Roberta, Giliberto, Luca, Pardini, Matteo, Pollero, Valeria, Novello, Cristina, Fornaro, Michele, Vitali, Antonella, Bracco, Laura, Caltagirone, Carlo, Bossù, Paola, Odetti, Patrizio, Tabaton, Massimo |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Down syndrome medicine.medical_specialty Amyloid beta-Peptide Amyloid Amyloid beta Amnesia Neuropsychological Tests behavioral disciplines and activities Gastroenterology Statistics Nonparametric Cohort Studies Cognition Disorder Peptide Fragment Internal medicine mental disorders medicine Dementia Humans Psychiatry Aged Amyloid beta-Peptides biology General Neuroscience Prodromal Stage General Medicine medicine.disease Peptide Fragments nervous system diseases Psychiatry and Mental health Clinical Psychology Cohort biology.protein Disease Progression Neuropsychological Test Female Cohort Studie Geriatrics and Gerontology medicine.symptom Psychology Cognition Disorders Mental Status Schedule Human Cohort study |
| Popis: | Amnestic mild cognitive impairment (aMCI) is considered a prodromal stage of Alzheimer's disease (AD). We measured plasma levels of amyloid-beta40 (Abeta40) and Abeta42 in 191 subjects with aMCI. Seventy-nine of them were clinically followed for two years. In the total cohort of aMCI cases, the average level of Abeta42, as well as the Abeta42/Abeta40 ratio, was significantly higher than those of the 102 cognitively normal age-matched subjects. The aMCI cases that converted to probable AD within 2 years had higher levels of Abeta42 and, to a lesser extent, Abeta40 than the stable cases. However the large variability of measured values indicates that plasma Abeta is not a suitable marker of incipient AD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|