Relationship between Histamine Release and Leukotrienes Production from Human Basophils Derived from Atopic Dermatitis Donors
| Autor: | Katsuhiro Miura, Hiroichi Nagai, Takebumi Onda, Michitaka Shichijo, Yumiko Toida, Motohiro Ebisawa, Hirohisa Saito, Yoji Iikura |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Leukotrienes Allergy Adolescent medicine.medical_treatment Immunology chemical and pharmacologic phenomena Basophil Histamine Release Dermatitis Atopic Atopy chemistry.chemical_compound medicine Animals Humans Immunology and Allergy Child Interleukin 3 Leukotriene business.industry hemic and immune systems General Medicine Atopic dermatitis medicine.disease Antibodies Anti-Idiotypic Basophils medicine.anatomical_structure Cytokine chemistry Female Interleukin-3 lipids (amino acids peptides and proteins) Rabbits business Histamine |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000237104 |
| Popis: | Basophils are known to release histamine and to produce leukotrienes (LTs) following both IgE-dependent and -independent stimuli. Although there exist a few reports which examined the relationship between histamine release and LTs production, their conclusions were not always in agreement with each other. In the present study, we examined the relationship between histamine release and LTs production from basophils in the presence or absence of 1 ng/ml of interleukin-3 (IL-3). Normal basophils released a smaller amount of histamine and LTs than atopic determatitis (AD) basophils, when basophils were stimulated with an optimal concentration of anti-IgE antibody. When we examined the relationship of histamine release and LTs production from AD donors induced through Fc epsilon RI, we found a significant exponential correlation between these two mediators (R2 = 0.58 in the absence of IL-3, R2 = 0.83 in the presence of IL-3). Although IL-3 enhanced both histamine release and LTs production from AD donors, the relationship between these two mediators was not affected. In conclusion, there was an exponential correlation between histamine release and LTs production from AD basophils, which was not affected by the pretreatment with IL-3. |
| Databáze: | OpenAIRE |
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