Adjusting for heterogeneity in phase II trials by using a modified Simon’s two stage design spiced up with historical controls

Autor: Lanz, LM, Edelmann, D, Benner, A, Schäkel, U, Klose, C, Labrenz, J, Müller-Tidow, C, Schlenk, RF
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: 66. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V. (GMDS), 12. Jahreskongress der Technologie-und Methodenplattform für die vernetzte medizinische Forschung e.V. (TMF); 20210926-20210930; sine loco [digital]; DOCAbstr. 114 /20210924/
DOI: 10.3205/21gmds082
Popis: Introduction: Response rate in r/r AML heavily depends on already known molecular and clinical data ranging from below 10% in patients with complex karyotypes and increasing to at least 80% in patients with CEBPA-biallelic mutations. Thus, adjustment of trial results in comparison to [for full text, please go to the a.m. URL]
Databáze: OpenAIRE