Delayed-Type Hypersensitivity to Metals of Environmental Burden in Patients with Takotsubo Syndrome - Is There a Clinical Relevance?
| Autor: | Petr Lokaj, Roman Miklík, L. Dostálová, Marie Pavlušová, Petr Nemec, Vera Stejskal, Petr Kala, Jiri Jarkovsky, Klára Benešová, Petr Kubena, Andrea Zadáková, J Manousek, Jiri Parenica, Jindrich Spinar |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Allergy Pulmonology lcsh:Medicine Arthritis Pilot Projects 030204 cardiovascular system & hematology Lymphocyte Activation Gastroenterology Biochemistry Arthritis Rheumatoid White Blood Cells 0302 clinical medicine Catecholamines Animal Cells Medicine and Health Sciences Hypersensitivity Delayed 030212 general & internal medicine Lymphocytes Amines lcsh:Science Aged 80 and over Multidisciplinary Organic Compounds Neurochemistry Neurotransmitters Middle Aged 3. Good health Chemistry Myocarditis Metals Rheumatoid arthritis Physical Sciences Female Cellular Types Research Article Chemical Elements Adult medicine.medical_specialty Biogenic Amines Mercury (Element) Pollutants Immune Cells Drug allergy Immunology Cardiology Environment Drug Hypersensitivity 03 medical and health sciences Takotsubo Cardiomyopathy Internal medicine medicine Hypersensitivity Humans Environmental Chemistry Medical history Clinical significance Pathological Asthma Aged Blood Cells business.industry lcsh:R Organic Chemistry Ecology and Environmental Sciences Chemical Compounds Biology and Life Sciences Mercury Cell Biology medicine.disease Hormones Oxidative Stress lcsh:Q Clinical Immunology Clinical Medicine business Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Vol 11, Iss 11, p e0164786 (2016) |
| ISSN: | 1932-6203 |
| Popis: | Objective Takotsubo syndrome (TS) is a heart condition characterised by a sudden transient left ventricular dysfunction; its pathophysiology is probably associated with elevated levels of catecholamines but the exact mechanism is not known as yet. Literature and clinical experience suggest that TS affects persons with various comorbidities. This pilot work aims to evaluate the frequency of comorbidities with potential pathological immune reactivity, and to evaluate the potential association between TS and hypersensitivity to metals assessed by LTT-MELISA (R). Methodology, Results A total of 24 patients (23 women, 1 man) with a history of TS attack and 27 healthy controls were evaluated. Hypersensitivity was evaluated by a lymphocyte transformation test (LTT-MELISA (R)); a questionnaire of environmental burden was used to select evaluated metals. A total of 19 patients (79%) had at least one condition that might potentially be associated with pathological immune reactivity (autoimmune thyroid disease, drug allergy, bronchial asthma, cancer, contact dermatitis, rheumatoid arthritis). Hypersensitivity to metals was identified significantly more frequently in TS patients than in healthy controls (positive reaction to at least one metal was identified in 95.8% of TS patients and in 59.3% of controls; p = 0.003); the difference was statistically significant for mercury (45.8% and 14.8%, respectively; p = 0.029). Conclusion Our work shows that conditions with pathological immune reactivity occur frequently in TS patients, and our data suggest a possible association between TS and hypersensitivity tometals (mercury in particular) evaluated by LTT-MELISA (R). We also suggest that apart from the triggering stress factor, potential existence of other serious conditions should be considered when taking medical history of TS patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|