Statistical association of rs2243250 polymorphism of IL4 gene and hemorrhagic stroke in Brazilian population
| Autor: | Hélia Carla Souza, Ângelo M. Rolim, Luzitano Brandão Ferreira, Felipe Borges, Jonathan D. Lima, Fabiana Brandão Alves Silva, Daniel Oliveira Freire, Izabel Cristina Rodrigues da Silva, Aline Ribeiro Barros |
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| Jazyk: | angličtina |
| Předmět: |
Oncology
medicine.medical_specialty business.industry Clinical Biochemistry hemorragias intracraneales Correlation and dependence Single-nucleotide polymorphism medicine.disease Phenotype polimorfismo de nucleótide simple Pathology and Forensic Medicine aneurisma intracraneal Medical Laboratory Technology Polymorphism (computer science) interleucina-4 Internal medicine Genotype medicine lcsh:Pathology accidente cerebrovascular business Stroke Gene Interleukin 4 lcsh:RB1-214 |
| Zdroj: | Jornal Brasileiro de Patologia e Medicina Laboratorial, Vol 56 |
| ISSN: | 1678-4774 1676-2444 |
| Popis: | Interleukin-4 (IL-4) has great significance in inflammatory processes in cases of stroke, since it is able to polarize microglia to the antiinflammatory phenotype called M2. This study analyzed if the variation between TT genotype and the other genotypes (CT and CC), in -589 (rs2243250) polymorphism of IL4 gene, has association with the prognosis of hemorrhagic stroke (HS) and with clinical aspects which are risk factors for cerebrovascular diseases. The result of this study shows that there is no statistical association of the IL4 polymorphism with either prognosis or clinical aspects in HS patients. |
| Databáze: | OpenAIRE |
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