High prevalence rates of adult silent coeliac disease, as seen in Sweden, must be expected in Denmark
| Autor: | Thomas Skogh, B Cavell, Ewa Grodzinsky, Robert Jordal, Birgitte Weile, Peter A. Krasilnikoff |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Adolescent Denmark Population Muscle Fibers Skeletal Blood Donors Coeliac disease Antibodies Gliadin Pathology and Forensic Medicine Danish Internal medicine Immunopathology Biopsy Epidemiology medicine Immunology and Allergy Humans Mass Screening education Aged Autoantibodies Sweden education.field_of_study medicine.diagnostic_test biology business.industry General Medicine Middle Aged medicine.disease language.human_language Immunoglobulin A Celiac Disease Anti-gliadin antibodies Immunology language biology.protein Female Antibody business |
| Zdroj: | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 109(11) |
| ISSN: | 0903-4641 |
| Popis: | Aim: To disclose the prevalence of adult "silent" coeliac disease in Denmark and Sweden. Experimental design: 1573 Danish and 1866 Swedish healthy blood donors were screened for the presence of serum anti-gliadin antibodies (AGA) by enzyme-linked immunosorbent assay. AGA-positive serum samples were further analysed for IgA anti-endomysium antibodies (EmA) by indirect immunofluorescence microscopy. Main results: The Danish donor population had a higher mean age than the Swedish (41.4 years versus 37.6 years) and a higher proportion of females (41% versus 32%), and had a lower mean level of AGA (17.3 units versus 20.6 units). Sixty-one (3.9%) Danish donors had AGA above the cut-off limit, and four of these also had positive EmA tests. Sixty (3.2%) Swedish donors had AGA above the cut-off limit, and five of these also had positive EmA. Coeliac pathology was proven by biopsy in all five coeliac disease-suspected Swedish donors. No small intestinal biopsy was performed in the coeliac disease-suspected Danish donors. Conclusions: Based upon the finding of EmA in AGA-positive serum samples, silent coeliac disease may be suspected in 1 per 394 Danish blood donors (2.5 per 1,000). A similar rate was proven in 1 per 373 Swedish blood donors (2.7 per 1,000), indicating no major differences in the prevalence of adult silent coeliac disease between the two neighbouring countries. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text