Genome-wide expression reveals multiple systemic effects associated with detection of anticoagulant poisons in bobcats (Lynx rufus)
| Autor: | Alice Mouton, Seth P. D. Riley, Laurel E. K. Serieys, Steve W. Cole, Sue VandeWoude, Robert K. Wayne, Scott Carver, Michael R. Lappin, Devaughn L. Fraser |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Food Chain Population 010501 environmental sciences Biology Adaptive Immunity 01 natural sciences California Xenobiotics 03 medical and health sciences chemistry.chemical_compound Secondary poisoning Genetics Animals education Gene Ecology Evolution Behavior and Systematics 0105 earth and related environmental sciences education.field_of_study Principal Component Analysis Innate immune system Genome Gene Expression Profiling Anticoagulants Rodenticides Environmental exposure Environmental Exposure Acquired immune system Endoplasmic Reticulum Stress Immunity Innate Gene expression profiling 030104 developmental biology chemistry Lynx Environmental Pollutants Disease Susceptibility Xenobiotic |
| Zdroj: | Molecular ecology. 27(5) |
| ISSN: | 1365-294X |
| Popis: | Anticoagulant rodenticides (ARs) are indiscriminate toxicants that threaten nontarget predatory and scavenger species through secondary poisoning. Accumulating evidence suggests that AR exposure may have disruptive sublethal consequences on individuals that can affect fitness. We evaluated AR-related effects on genome-wide expression patterns in a population of bobcats in southern California. We identify differential expression of genes involved in xenobiotic metabolism, endoplasmic reticulum stress response, epithelial integrity and both adaptive and innate immune function. Further, we find that differential expression of immune-related genes may be attributable to AR-related effects on leucocyte differentiation. Collectively, our results provide an unprecedented understanding of the sublethal effects of AR exposure on a wild carnivore. These findings highlight potential detrimental effects of ARs on a wide variety of species worldwide that may consume poisoned rodents and indicate the need to investigate gene expression effects of other toxicants added to natural environments by humans. |
| Databáze: | OpenAIRE |
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