The Participation of a Malignant Catarrhal Fever Virus and Mycoplasma bovis in the Development of Single and Mixed Infections in Beef and Dairy Cattle With Bovine Respiratory Disease
| Autor: | Thalita Evani Silva Oliveira, Gabriela Sanches Scuisato, Isadora Fernanda Pelaquim, Cristina Wetzel Cunha, Lucas Santana Cunha, Eduardo Furtado Flores, Lucienne Garcia Pretto-Giordano, Júlio Augusto Naylor Lisbôa, Amauri Alcindo Alfieri, João Paulo Elsen Saut, Paulo Henrique Jorge da Cunha, Selwyn Arlington Headley |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
040301 veterinary sciences
Veterinary medicine viruses Malignant catarrhal fever virus Bovine respiratory disease Virus ovine gammaherpesvirus 2 0403 veterinary science 03 medical and health sciences Antigen fibrinoid change SF600-1100 proliferative vascular alterations Medicine respiratory disease pathogens Dairy cattle Original Research 0303 health sciences diagnostic immunohistochemistry General Veterinary 030306 microbiology business.industry 04 agricultural and veterinary sciences medicine.disease Virology caseonecrotic bronchopneumonia Pneumonia Infectious disease (medical specialty) histopathologic patterns Immunohistochemistry Veterinary Science business |
| Zdroj: | Frontiers in Veterinary Science Frontiers in Veterinary Science, Vol 8 (2021) |
| ISSN: | 2297-1769 |
| Popis: | The bovine respiratory disease (BRD) complex is a multietiological and multifactorial disease associated with a wide range of viral and bacterial pathogens. This study evaluated the contribution of specific infectious disease agents in the development of BRD in cattle from Brazil and determined if a virus within the malignant catarrhal fever virus (MCFV) group and Mycoplasma bovis, acting individually or in conjunction, can be associated with the development of BRD. Formalin-fixed paraffin-embedded pulmonary sections were used in immunohistochemical assays to determine the intralesional presence of six antigens associated with BRD: bovine alphaherpesvirus 1 (BoHV-1), bovine parainfluenza virus 3 (BPIV-3), bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV), MCFV, and M. bovis. Pneumonia was diagnosed in 82.7% (120/145) of all cattle evaluated. Interstitial pneumonia (60%, 72/120) and suppurative bronchopneumonia (25.8%, 31/120) were the most frequent patterns of pneumonia identified. Intralesional antigens of MCFV (53.3%, 64/120) were the most frequently associated with BRD, followed by M. bovis (47.5%, 57/120), BVDV (42.5%, 51/120), BoHV-1 (28.3%, 34/120), BRSV (24.2%, 29/120), and BPIV-3 (8.3%, 10/120). Additionally, antigens of BVDV, MCFV, and M. bovis were the most frequently identified agents associated with singular and concomitant infections. The MCFV identified during this study is more likely to be ovine gammaherpesvirus 2 (OvHV-2), since OvHV-2 is the only MCFV identified within the geographical region of this study. Interstitial pneumonia with proliferative vascular lesions may be a useful histologic feature to differentiate MCFV-induced pneumonia from other viral pneumonias of cattle. These results demonstrate that MCFV and M. bovis, in single or mixed infections, can produce pneumonia in cattle and should therefore be considered as primary agents in the development of BRD. |
| Databáze: | OpenAIRE |
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