Pharmacokinetics of amphotericin B colloidal dispersion in critically ill patients with cholestatic liver disease
| Autor: | Stefan Weiler, Eva Stienecke, Stefan Dunzendorfer, Julia Schöfmann, Elisabeth Überlacher, Romuald Bellmann, Michael Joannidis |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Antifungal Agents Adolescent animal diseases Critical Illness Gastroenterology Young Adult Pharmacokinetics Internal medicine Amphotericin B parasitic diseases Medicine Humans Pharmacology (medical) In patient Amphotericin B Colloidal Dispersion Colloids Child Aged Pharmacology Normal liver function business.industry Critically ill urogenital system Liver Diseases technology industry and agriculture Middle Aged bacterial infections and mycoses Infectious Diseases Critical illness Immunology Female Cholestatic liver disease business medicine.drug |
| Zdroj: | Antimicrobial agents and chemotherapy. 56(10) |
| ISSN: | 1098-6596 |
| Popis: | The pharmacokinetics of lipid-bound and liberated amphotericin B (AMB) was assessed in 11 critically ill patients with cholestatic liver disease (CSLD) and in 9 subjects with normal liver function treated with AMB colloidal dispersion (ABCD). Exposure to lipid-bound AMB was higher in patients with CSLD. Levels of liberated AMB were elevated by CSLD only after the first dose, whereas its pharmacokinetics was unaffected at steady state. The standard dosage of ABCD is probably adequate for patients with CSLD. |
| Databáze: | OpenAIRE |
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