Is strongyloidiasis currently autochthonous in Croatia? A retrospective study
| Autor: | Domagoj Tomasović, Mirjana Balen Topić, Mario Sviben, Ena Marjanović |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Croatia Asymptomatic Strongyloides stercoralis Albendazole Serology Ivermectin Internal medicine Epidemiology Animals Humans Medicine Eosinophilia Retrospective Studies biology business.industry Public Health Environmental and Occupational Health General Medicine biology.organism_classification medicine.disease Infectious Diseases Strongyloidiasis autochthonous clinical presentation diagnostics endemicity strongyloidiasis Parasitology medicine.symptom business medicine.drug |
| Zdroj: | Transactions of The Royal Society of Tropical Medicine and Hygiene. 115:1298-1303 |
| ISSN: | 1878-3503 0035-9203 |
| DOI: | 10.1093/trstmh/trab139 |
| Popis: | Background Autochthonous human infections with Strongyloides stercoralis have been well documented in many European regions. By exploring patients’ data, we aimed to find elements for its current endemicity in Croatia. Methods This retrospective descriptive study analysed epidemiological and clinical data of patients treated for strongyloidiasis from January 2010 to May 2019 at a teaching hospital in Zagreb, Croatia. The diagnosis was made by direct methods using light microscopy and/or serology. Results Among 65 patients with strongyloidiasis, 60% were men, and 78.5% were 50–79 y of age. The sensitivity of the examination of three stool samples after concentration, saline provocation and serology was 26.2, 80.7 and 86.2%, respectively. Clinical presentation included asymptomatic patients with eosinophilia (41.5%), chronic symptomatic infection (33.8%), acute infection (18.5%) and hyperinfection (6.2%). Twenty patients (30.8%) were immunosuppressed; among four of whom developed hyperinfection, two died. Initially 71.7% of patients were treated with albendazole and 13.3% with ivermectin, with an equal parasitological cure rate (72.2% and 75%; p=0.09). In 11 patients, acute infection was autochthonous in its origin. Conclusions Strongyloidiasis is currently endemic in Croatia and immunosuppressed travellers to this region should be advised to take precautions. Patients undergoing immunosuppression and organ donors from Croatia should be screened. |
| Databáze: | OpenAIRE |
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