Preparation and characterization of etoricoxib-β-cyclodextrin complexes prepared by the kneading method
| Autor: | Bhanubhai N Suhagia, Shailesh A. Shah, Vijay K. Parmar, Ishwar Sinh Rathod, HM Patel |
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| Rok vydání: | 2007 |
| Předmět: |
Pyridines
Chemistry Pharmaceutical Drug Compounding Pharmaceutical Science Infrared spectroscopy Calorimetry Etoricoxib Differential scanning calorimetry X-Ray Diffraction Spectroscopy Fourier Transform Infrared medicine Cyclooxygenase Inhibitors Sulfones Binary system Solubility Dissolution Pharmacology chemistry.chemical_classification Chromatography Calorimetry Differential Scanning Cyclodextrin Chemistry beta-Cyclodextrins General Medicine Powder Diffraction medicine.drug Nuclear chemistry |
| Zdroj: | Acta Pharmaceutica. 57 |
| ISSN: | 1846-9558 1330-0075 |
| DOI: | 10.2478/v10007-007-0028-2 |
| Popis: | The binary system of etoricoxib with beta-cyklodextrin (beta-CD) was prepared by the kneading method. Drug-cyclodextrin interactions in solution were investigated by the phase solubility analysis. Differential scanning calorimetry, infrared spectroscopy, powder X-ray diffractometry and microscopic study were used to characterize the solid state of all binary systems, whereas their dissolution properties were evaluated according to the USP XXIII paddle method. The results indicate partial interaction of the drug with beta-CD in the physical mixture and complete interaction in the kneaded complex. The dissolution of etoricoxib was notably increased as compared to pure drug as well as its physical mixture. The complex showed more than 75% drug released in 30 min. |
| Databáze: | OpenAIRE |
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