The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?
| Autor: | Miguel Á. Tejada, Inmaculada Bravo-Caparrós, Ángeles Montilla-García, Rafael González-Cano, Enrique J. Cobos, M. Carmen Ruiz-Cantero, Francisco R. Nieto |
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| Rok vydání: | 2019 |
| Předmět: |
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medicine.medical_specialty Cognitive Neuroscience Analgesic MEDLINE Exploratory activity Pain Emotional functioning Affect (psychology) Postural changes Behavioral Neuroscience Physical medicine and rehabilitation Pain assessment Medicine Animals Animal model Burrowing Nesting Pain Measurement Facial expression Behavior Analgesics Sex Characteristics business.industry Wheel running Intracranial self-stimulation Facial expressions Disease Models Animal Neuropsychology and Physiological Psychology Drug development Grip strength Female Home cage activity Analgesia business Tail flick test |
| Zdroj: | Digibug: Repositorio Institucional de la Universidad de Granada Universidad de Granada (UGR) Digibug. Repositorio Institucional de la Universidad de Granada Consejo Superior de Investigaciones Científicas (CSIC) |
| ISSN: | 1873-7528 |
| Popis: | Pain measures traditionally used in rodents record mere reflexes evoked by sensory stimuli; the results thus may not fully reflect the human pain phenotype. Alterations in physical and emotional functioning, pain-depressed behaviors and facial pain expressions were recently proposed as additional pain outcomes to provide a more accurate measure of clinical pain in rodents, and hence to potentially enhance analgesic drug development. We aimed to review how preclinical pain assessment has evolved since the development of the tail flick test in 1941, with a particular focus on a critical analysis of some nonstandard pain outcomes, and a consideration of how sex differences may affect the performance of these pain surrogates. We tracked original research articles in Medline for the following periods: 1973-1977, 1983-1987, 1993-1997, 2003-2007, and 2014-2018. We identified 606 research articles about alternative surrogate pain measures, 473 of which were published between 2014 and 2018. This indicates that preclinical pain assessment is moving toward the use of these measures, which may soon become standard procedures in preclinical pain laboratories. FPU grant from the Spanish Ministry of Education, Culture and Sports Spanish Ministry of Economy and Competitiveness (MINECO, grant SAF2016-80540-R) Ramón Areces Foundation Junta de Andalucía (grant CTS 109) Esteve Pharmaceuticals European Regional Development Fund (ERDF) |
| Databáze: | OpenAIRE |
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