Economic evaluation of health consequences of prenatal methylmercury exposure in France
| Autor: | Céline Pichery, Anne Roue-LeGall, Nadine Fréry, Philippe Grandjean, Denis Zmirou-Navier, Philippe Hartemann, Sylvaine Cordier, Martine Bellanger |
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| Přispěvatelé: | École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Département santé environnement, Institut de Veille Sanitaire (INVS), Service de Santé Publique, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Institute of Public Health, University of Southern Denmark (SDU), Department of Environmental Health, Harvard School of Public Health, BMC, Ed., Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Economics
Health Toxicology and Mutagenesis Intelligence 010501 environmental sciences 01 natural sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy Prenatal exposure Medicine 030212 general & internal medicine Economic impact analysis Methylmercury Maternal-Fetal Exchange Intelligence Tests Intelligence quotient lcsh:Public aspects of medicine Environmental exposure Methylmercury Compounds Middle Aged 8. Economic growth lcsh:Industrial medicine. Industrial hygiene Environmental Pollutants Female France Environmental Monitoring Adult medicine.medical_specialty Adolescent Neurodevelopmental deficits 03 medical and health sciences Young Adult lcsh:RC963-969 Environmental health Humans 0105 earth and related environmental sciences Health consequences business.industry Public health Research Public Health Environmental and Occupational Health lcsh:RA1-1270 Environmental Exposure Economic evaluation chemistry [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business Hair |
| Zdroj: | Environmental Health, Vol 11, Iss 1, p 53 (2012) Environmental Health Environmental Health, 2012, 11 (1), pp.53. ⟨10.1186/1476-069X-11-53⟩ Environmental Health, BioMed Central, 2012, 11 (1), pp.53. ⟨10.1186/1476-069X-11-53⟩ Pichery, C, Bellanger, M, Zmirou-Navier, D, Fréry, N, Cordier, S, Roue-Legall, A, Hartemann, P & Grandjean, P 2012, ' Economic evaluation of health consequences of prenatal methylmercury exposure in France ', Environmental Health: A Global Access Science Source, vol. 11, no. 53 . https://doi.org/10.1186/1476-069X-11-53 |
| ISSN: | 1476-069X |
| DOI: | 10.1186/1476-069X-11-53⟩ |
| Popis: | Background Evidence of a dose–response relationship between prenatal exposure to methylmercury (MeHg) and neurodevelopmental consequences in terms of IQ reduction, makes it possible to evaluate the economic consequences of MeHg exposures. Objective To perform an economic evaluation of annual national benefits of reduction of the prenatal MeHg exposure in France. Methods We used data on hair-Hg concentrations in French women of childbearing age (18–45 years) from a national sample of 126 women and from two studies conducted in coastal regions (n = 161and n = 503). A linear dose response function with a slope of 0.465 IQ point reduction per μg/g increase in hair-Hg concentration was used, along with a log transformation of the exposure scale, where a doubling of exposure was associated with a loss of 1.5 IQ points. The costs calculations utilized an updated estimate of €2008 17,363 per IQ point decrement, with three hypothetical exposure cut-off points (hair-Hg of 0.58, 1.0, and 2.5 μg/g). Results Because of higher exposure levels of women in coastal communities, the annual economic impacts based on these data were greater than those using the national data, i.e. € 1.62 billion (national), and € 3.02 billion and € 2.51 billion (regional), respectively, with the linear model, and € 5.46 billion (national), and € 9.13 billion and € 8.17 billion (regional), with the log model, for exposures above 0.58 μg/g. Conclusions These results emphasize that efforts to reduce MeHg exposures would have high social benefits by preventing the serious and lifelong consequences of neurodevelopmental deficits in children. |
| Databáze: | OpenAIRE |
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