Efficacy and tolerance of intravenous prostaglandins F2α and E2
| Autor: | V Brotanek, C.H. Hendricks, Jr Ji Fishburne, William E. Brenner, L Ekbladh |
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| Rok vydání: | 1971 |
| Předmět: |
Time Factors
Fever Vomiting Nausea Rate of infusion Prostaglandin Abortion Curettage chemistry.chemical_compound Pregnancy Oxytocics medicine Humans Abortion Therapeutic Abortifacient Clinical Trials as Topic business.industry Uterus Obstetrics and Gynecology Blood Pressure Determination medicine.disease Therapeutic abortion chemistry Anesthesia Injections Intravenous Prostaglandins Female lipids (amino acids peptides and proteins) medicine.symptom Phlebitis business |
| Zdroj: | American Journal of Obstetrics and Gynecology. 111:564-579 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/0002-9378(71)90473-x |
| Popis: | With the increasing needs and demand for a safe, convenient abortifacient, the most promising of the natural prostaglandins, PGE 2 and PGF 2α , were investigated by the random, double-blind, intravenous-infusion technique to: (1) compare their abortifacient and oxytoxic activity; (2) determine the complications and their frequency in therapeutic dosage; (3) derive an infusion dosage with maximum effectiveness and minimum complications. Ten gravidas, from 7 to 20 weeks pregnant, desiring therapeutic abortion were infused with PGE 2 and PGF 2α between 2.5 and 20 μg per minute and 25 and 200 μg per minute, respectively, in progressively increasing doses for 12 hours. Both PGE 2 and PGF 2α were effective abortifacients. Nausea, emesis, and fever (temperature > 100° F.) complicated PGF 2α and increased in severity and frequency with progressive rates of infusion. Sixty per cent of the patients infused with 5 μg of PGE 2 per minute developed a transient phlebitis which increased in intensity with higher rates of infusion. The percentage of patients developing the minimum amount of uterine activity observed wth abortion increased as the rates of prostaglandin infusion were increased. No one infusion rate of either prostaglandin would produce a maximum rate of abortion with minimum complications. To attain this goal, it is recommended that the individual patient receive a progressively increasing rate of infusion until adequate uterine activity is achieved. |
| Databáze: | OpenAIRE |
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