A Plasmodium yoelii soluble factor inhibits the phenotypic maturation of dendritic cells
| Autor: | Jamie M. Orengo, Kurt A Wong, Ana Rodriguez, Carlos Ocaña-Morgner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Cell Extracts
Erythrocytes lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Plasmodium Immune tolerance lcsh:Infectious and parasitic diseases 03 medical and health sciences Mice 0302 clinical medicine Immune system In vivo parasitic diseases Immune Tolerance Animals lcsh:RC109-216 030304 developmental biology 0303 health sciences Mice Inbred BALB C biology Research Dendritic Cells Plasmodium yoelii biology.organism_classification Phenotype In vitro 3. Good health Cell biology Infectious Diseases Cytokines Cytokine secretion Female Parasitology 030215 immunology |
| Zdroj: | Malaria Journal, Vol 7, Iss 1, p 254 (2008) Malaria Journal |
| ISSN: | 1475-2875 |
| Popis: | BackgroundInfection with the protozoan parasitePlasmodiumis the cause of malaria.Plasmodiuminfects host erythrocytes causing the pathology of the disease.Plasmodium-infected erythrocytes can modulate the maturation of dendritic cells (DCs) and alter their capacity to activate T cells.MethodsMice infected withPlasmodium yoeliiand isolatedP. yoelii-infected erythrocytes were used to study their effect on the maturation of mouse dendritic cells.ResultsDCs are not able to mature in response to LPS injection during the late stage ofP. yoeliiinfection in mice, indicating impaired functionality of these cellsin vivo.P. yoelii-infected erythrocytes inhibit the maturation of DCsin vitroin a dose-dependent manner, which is consistent with the inhibition found during late infection when parasite burden is highest. The inhibition of DC maturation and the cytokine secretion profile of DCs are modulated by soluble factors released byP. yoelii-infected erythrocytes. A small, heat-stable, non-hydrophobic molecule ofP. yoelii-infected erythrocytes rapidly inhibits the LPS induced phenotypic maturation of DCs in a reversible manner.ConclusionThese findings add evidence to the malaria associated immune suppressionin vivoandin vitroand provide insight into the nature and mechanism of thePlasmodiumfactor(s) responsible for altering DC functions. |
| Databáze: | OpenAIRE |
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